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Maternal exposure to butyl paraben impairs testicular structure and sperm quality on male rats.
Guerra, Marina T; Sanabria, Marciana; Leite, Gabriel A A; Borges, Cibele S; Cucielo, Maira S; Anselmo-Franci, Janete A; Foster, W G; Kempinas, W G.
Afiliação
  • Guerra MT; Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito De Rubião Jr S/N, Botucatu, Sao Paulo, 18618-970, Brazil.
  • Sanabria M; Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito De Rubião Jr S/N, Botucatu, Sao Paulo, 18618-970, Brazil.
  • Leite GA; Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito De Rubião Jr S/N, Botucatu, Sao Paulo, 18618-970, Brazil.
  • Borges CS; Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito De Rubião Jr S/N, Botucatu, Sao Paulo, 18618-970, Brazil.
  • Cucielo MS; Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito De Rubião Jr S/N, Botucatu, Sao Paulo, 18618-970, Brazil.
  • Anselmo-Franci JA; Laboratory of Reproductive Neuroendocrinology, Department of Morphology, Stomatology and Physiology, School of Dentistry, University of São Paulo, USP, Avenida Do Café S/N, Ribeirão Preto, Sao Paulo, 14040904, Brazil.
  • Foster WG; Department of Obstetrics and Gynecology, Division of Reproductive Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
  • Kempinas WG; Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito De Rubião Jr S/N, Botucatu, Sao Paulo, 18618-970, Brazil.
Environ Toxicol ; 32(4): 1273-1289, 2017 Apr.
Article em En | MEDLINE | ID: mdl-27444704
Parabens are hormonally active chemicals widely used as preservatives in foods and are frequently detected in human fluids and tissues. Therefore, the objective of this study was to determine the effects of maternal butyl paraben (BP) exposure on male sexual development. Pregnant Wistar rats received corn oil (control group), or BP at doses of 10, 100, or 200 mg/kg, subcutaneously, from gestational day 12 until postnatal day 21. Our results demonstrated that developmental BP exposure significantly increased the number of adult Leydig cells and the circulating concentrations of testosterone and attenuated FSH and LH concentrations at 200 mg/kg. BP exposure adversely affected spermatogenesis kinetics at doses of 10 and 200 mg/kg and provoked a decrease in the immunostaining of EsR1 and AR at 200 mg/kg. The sperm motility was impaired at the 10 mg/kg dose, and sperm head abnormalities were increased in all BP dose groups. We suggest that BP impairs testicular structure and function in the rat, affecting sperm quality. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1273-1289, 2017.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parabenos / Espermatozoides / Testículo Limite: Animals / Pregnancy Idioma: En Revista: Environ Toxicol Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parabenos / Espermatozoides / Testículo Limite: Animals / Pregnancy Idioma: En Revista: Environ Toxicol Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos