Longitudinal Evaluation of Central Corneal Thickness in Patients With Systemic Sclerosis.
Cornea
; 35(12): 1584-1588, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-27442319
PURPOSE: To investigate the longitudinal change of central corneal thickness (CCT) in patients with systemic sclerosis (SSc) and to elucidate whether it contributes to misinterpretation of intraocular pressure (IOP) in this group of patients. METHODS: Twenty patients with SSc and 20 sex- and age-matched controls were examined at 2 visits 5 years apart. Age, sex, race, subtype of SSc, disease duration, autoantibody profile, use of disease-modifying antirheumatic drugs (DMARDs), best-corrected visual acuity, spherical equivalent refraction, IOP, and CCT were recorded. IOP was assessed by applanation tonometry and CCT by ultrasonic pachymetry. RESULTS: CCT decreased by 7.2 µm [95% confidence interval (CI), -2.1 to -12.2 µm] between the first and second measurements (P = 0.008) in patients with SSc and by 2.4 µm (P = 0.39, 95% CI, -8.0 to 3.3 µm) in the control group. Considering patients with SSc, CCT decreased by a mean of 11.6 µm [95% CI, -4.3 to -19.0 µm (P = 0.007)] among those taking DMARDs at the second visit and by 4.2 µm [95% CI, -3.0 to -11.5 µm (P = 0.2)] in patients not taking any DMARDs. There was no statistically significant change in IOP between the 2 visits for either the SSc group (P = 0.84) or the control group (P = 0.29). Mean change in CCT was not associated with either IOP at first visit or with change in IOP in SSc patients. CONCLUSIONS: CCT decreased with time in SSc. However, the slight rates of thinning observed are unlikely to considerably influence applanation tonometry or clinical decision-making over the short to intermediate term.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escleroderma Sistêmico
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Córnea
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Doenças da Córnea
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cornea
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos