[Health-Related Quality of Life in patients with hepatitis C treated with dual and triple therapy]. / Qualidade de vida relacionada à saúde em pacientes com hepatite C em terapia dupla e tripla.
Rev Esc Enferm USP
; 49(6): 939-45, 2015 Dec.
Article
em Pt
| MEDLINE
| ID: mdl-27419677
OBJECTIVE: Comparing Health-Related Quality of Life (HRQoL) scores in patients with chronic hepatitis C undergoing double and triple antiviral therapy and analyzing possible factors related to HRQoL. METHOD: HRQoL was assessed using the Short Form 36 and Chronic Liver Disease Questionnaire, which were applied at baseline and at weeks 4, 12 and 16 of treatment to 32 patients divided into two groups: double therapy with pegylated interferon (IFN-PEG) and ribavirin, and triple therapy with PEG-IFN, ribavirin and telaprevir. RESULTS: The reduction of HRQoL was greater in patients receiving triple therapy compared to those treated with two drugs, the most critical time is at 12 weeks in both groups. After removal of telaprevir, the triple therapy group significantly improved their HRQoL scores. Anxiety and depression before treatment, employment status and race are significantly related to diminished HRQoL. CONCLUSION: Patients undergoing double and triple therapy have diminished HRQoL indexes, but the addition of telaprevir chooses a more significant decrease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Oligopeptídeos
/
Polietilenoglicóis
/
Qualidade de Vida
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Ribavirina
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Interferon-alfa
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Hepatite C Crônica
Aspecto:
Patient_preference
Limite:
Female
/
Humans
/
Male
Idioma:
Pt
Revista:
Rev Esc Enferm USP
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil