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Zoledronate as effective treatment for minimal trauma fractures in a child with STAT3 deficiency and osteonecrosis of the hip.
Staines Boone, Aidé Tamara; Alcántara-Montiel, Julio César; Sánchez-Sánchez, Luz María; Arce-Cano, Marina; García-Campos, Jorge; Lugo Reyes, Saúl Oswaldo.
Afiliação
  • Staines Boone AT; Clinical Immunology Department, Hospital de Especialidades, Mexican Social Security Institute (IMSS), Monterrey, Nuevo León, Mexico. tamarastaines@gmail.com.
  • Alcántara-Montiel JC; Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV), National Polytechnic Institute (IPN), Mexico City, Mexico.
  • Sánchez-Sánchez LM; Department of Pediatrics, Hospital de Especialidades, Mexican Social Security Institute (IMSS), Monterrey, Nuevo León, Mexico.
  • Arce-Cano M; Department of Pediatrics, Hospital de Especialidades, Mexican Social Security Institute (IMSS), Monterrey, Nuevo León, Mexico.
  • García-Campos J; Department of Infectious Diseases, Hospital de Especialidades, Mexican Social Security Institute (IMSS), Monterrey, Nuevo León, Mexico.
  • Lugo Reyes SO; Immunodeficiencies Research Unit, National Institute of Pediatrics (INP), Mexico City, Mexico.
Pediatr Blood Cancer ; 63(11): 2054-7, 2016 11.
Article em En | MEDLINE | ID: mdl-27416072
Signal transducer and activator of transcription 3 (STAT3) deficiency is a primary immunodeficiency characterized by eczema, complicated recurrent infections, elevated serum immunoglobulin E (IgE), osteopenia, and minimal trauma fractures. Zoledronic acid (ZA) is a long-acting bisphosphonate that has been successfully used in children with secondary osteoporosis and osteogenesis imperfecta. We describe the case of a 7-year-old male with STAT3 deficiency and minimal trauma fractures, who also developed osteonecrosis of the hip. He responded well to intravenous ZA every 6 months for 18 months. Three years later, he walks independently and unaided, and has not suffered any other fractures. Although more studies are needed, ZA might help reduce minimal trauma fractures in patients with STAT3 deficiency.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteonecrose / Difosfonatos / Fraturas Ósseas / Fator de Transcrição STAT3 / Conservadores da Densidade Óssea / Quadril / Imidazóis Tipo de estudo: Etiology_studies Limite: Child / Humans / Male Idioma: En Revista: Pediatr Blood Cancer Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteonecrose / Difosfonatos / Fraturas Ósseas / Fator de Transcrição STAT3 / Conservadores da Densidade Óssea / Quadril / Imidazóis Tipo de estudo: Etiology_studies Limite: Child / Humans / Male Idioma: En Revista: Pediatr Blood Cancer Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos