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The regulation of hematopoietic stem cell populations.
Mayani, Hector.
Afiliação
  • Mayani H; Hematopoietic Stem Cells Laboratory, Oncology Research Unit, IMSS National Medical Center, Mexico City, Mexico.
F1000Res ; 52016.
Article em En | MEDLINE | ID: mdl-27408695
Evidence presented over the last few years indicates that the hematopoietic stem cell (HSC) compartment comprises not just one but a number of different cell populations. Based on HSCs' proliferation and engraftment potential, it has been suggested that there are two classes of HSC, with long- and short-term engraftment potential. HSC heterogeneity seems to involve differentiation capacities as well, since it has been shown that some HSC clones are able to give rise to both myeloid and lymphoid progeny, whereas others are lymphoid deficient. It has been recognized that HSC function depends on intrinsic cell regulators, which are modulated by external signals. Among the former, we can include transcription factors and non-coding RNAs as well as epigenetic modifiers. Among the latter, cytokines and extracellular matrix molecules have been implicated. Understanding the elements and mechanisms that regulate HSC populations is of significant relevance both in biological and in clinical terms, and research in this area still has to face several complex and exciting challenges.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: F1000Res Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: F1000Res Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido