Your browser doesn't support javascript.
loading
Effects of Lentinula edodes consumption on biochemical, hematologic and oxidative stress parameters in rats receiving high-fat diet.
Spim, Sara Rosicler Vieira; de Oliveira, Bruna Giovanna Corrêa Chrispim; Leite, Fernanda Gomes; Gerenutti, Marli; Grotto, Denise.
Afiliação
  • Spim SRV; Laboratory of Toxicological Research, Rodovia Raposo Tavares, University of Sorocaba, Km 92.5, Sorocaba, São Paulo State, 18023-000, Brazil.
  • de Oliveira BGCC; Laboratory of Toxicological Research, Rodovia Raposo Tavares, University of Sorocaba, Km 92.5, Sorocaba, São Paulo State, 18023-000, Brazil.
  • Leite FG; Laboratory of Toxicological Research, Rodovia Raposo Tavares, University of Sorocaba, Km 92.5, Sorocaba, São Paulo State, 18023-000, Brazil.
  • Gerenutti M; Laboratory of Toxicological Research, Rodovia Raposo Tavares, University of Sorocaba, Km 92.5, Sorocaba, São Paulo State, 18023-000, Brazil.
  • Grotto D; Laboratory of Toxicological Research, Rodovia Raposo Tavares, University of Sorocaba, Km 92.5, Sorocaba, São Paulo State, 18023-000, Brazil. denise.grotto@prof.uniso.br.
Eur J Nutr ; 56(7): 2255-2264, 2017 Oct.
Article em En | MEDLINE | ID: mdl-27388463
PURPOSE: Functional foods can prevent/reduce the risks related to obesity. Lentinula edodes is a highly nutritious mushroom rich in protein, vitamins and minerals. Some studies have demonstrated the hypocholesterolemic effects from L. edodes in high doses, which does not represent the consumption in humans. We evaluated ingestion of a realistic dose of L. edodes associated with a high-fat diet (HFD) on hematologic, biochemical and oxidative stress parameters. METHODS: Eighteen male Wistar rats were divided into three groups: control (normal diet); HFD; and HFD + L. edodes (100 mg/kg/day). After 30 days, blood was collected. Biochemical and hematologic parameters were analyzed, as well as oxidative stress biomarkers. RESULTS: The HFD increased levels of total cholesterol and triglycerides. Lentinula edodes reduced these parameters significantly to concentrations found in the control group. The HFD increased levels of alanine transaminase and aspartate transaminase (markers of liver damage). Lentinula edodes returned the levels of these enzymes to normal levels and normalized serum levels of urea (which were also increased owing to consumption of the HFD). Lentinula edodes reduced levels of urea and glucose. Lipid peroxidation was increased in rats receiving the HFD, and L. edodes reduced malondialdehyde levels, thereby preventing oxidation of fatty acids. CONCLUSIONS: Lentinula edodes was shown to have hypolipidemic, hypoglycemic, hepatoprotective and renoprotective features in doses that are suitable for humans.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Cogumelos Shiitake / Alimento Funcional / Dieta Hiperlipídica Limite: Animals Idioma: En Revista: Eur J Nutr Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Cogumelos Shiitake / Alimento Funcional / Dieta Hiperlipídica Limite: Animals Idioma: En Revista: Eur J Nutr Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha