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Intersex and liver alterations induced by long-term sublethal exposure to 17α-ethinylestradiol in adult male Cnesterodon decemmaculatus (Pisces: Poeciliidae).
Young, Brian Jonathan; López, Gabriela Carina; Cristos, Diego Sebastián; Crespo, Diana Cristina; Somoza, Gustavo Manuel; Carriquiriborde, Pedro.
Afiliação
  • Young BJ; Laboratorio de Transformación de Residuos, Instituto de Microbiología y Zoología Agrícola, Instituto Nacional de Tecnología Agropecuaria, Castelar, Buenos Aires, Argentina.
  • López GC; Laboratorio de Ictiofisiología y Acuicultura, Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús (CONICET-UNSAM), Chascomús, Buenos Aires, Argentina.
  • Cristos DS; Laboratorio de Contaminantes Químicos, Instituto de Tecnología de Alimentos, Instituto Nacional de Tecnología Agropecuaria, Castelar, Buenos Aires, Argentina.
  • Crespo DC; Laboratorio de Transformación de Residuos, Instituto de Microbiología y Zoología Agrícola, Instituto Nacional de Tecnología Agropecuaria, Castelar, Buenos Aires, Argentina.
  • Somoza GM; Laboratorio de Ictiofisiología y Acuicultura, Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús (CONICET-UNSAM), Chascomús, Buenos Aires, Argentina.
  • Carriquiriborde P; Centro de Investigaciones del Medio Ambiente, Departamento de Química, Universidad Nacional de La Plata, CONICET, La Plata, Buenos Aires, Argentina.
Environ Toxicol Chem ; 36(7): 1738-1745, 2017 07.
Article em En | MEDLINE | ID: mdl-27381300
The aim of the present study was to assess the responses of the gonopodium morphology and the gonadal and liver histology of adult male Cnesterodon decemmaculatus to sublethal long-term exposure concentrations of 17α-ethinylestradiol (EE2). Two experiments were conducted exposing the fish to waterborne concentrations of EE2 ranging from 20 ng/L to 200 ng/L for 8 wk, 12 wk, and 16 wk. Intersex gonads were observed after 8 wk and 16 wk in fish exposed to 200 ng EE2/L and 100 ng EE2/L, respectively. Oocytes' development from testis germ cells and replacement of the efferent duct periodic acid-Schiff-positive secretion surrounding spermatozeugmata by parenchymal tissue and duct structure alterations were the major observed changes in the gonads. In contrast, no response was observed in the gonopodium morphology. Liver histology was also altered, showing increasing steatosis, single-cell necrosis to generalized necrosis, and disruption of acinar organization from 100 ng EE2/L to 200 ng EE2/L. In summary, the present results showed that although EE2 was not able to alter the morphology of a developed gonopodium, it was capable of inducing development of testicular oocytes in adult male C. decemmaculatus at environmentally relevant concentrations. Thus, externally normal but intersex C. decemmaculatus males would be expected in the wastewater-receiving streams that the species inhabits. According to the literature, the present study would be the first indicating estrogen-induced intersex in adult male poeciliid. Environ Toxicol Chem 2017;36:1738-1745. © 2016 SETAC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos do Desenvolvimento Sexual / Ciprinodontiformes / Etinilestradiol / Gônadas / Fígado Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Environ Toxicol Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos do Desenvolvimento Sexual / Ciprinodontiformes / Etinilestradiol / Gônadas / Fígado Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Environ Toxicol Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos