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Salivary levels of inflammatory cytokines and their association to periodontal disease in systemic lupus erythematosus patients. A case-control study.
Marques, Consuelo Penha Castro; Victor, Elis Cabral; Franco, Mayra Moura; Fernandes, José Mauro Carneiro; Maor, Yehoshua; de Andrade, Marcelo Souza; Rodrigues, Vandilson Pereira; Benatti, Bruno Braga.
Afiliação
  • Marques CP; School of Dentistry, Federal University of Maranhão, Avenida dos Portugueses, s/n, Campus Universitário do Bacanga, 65.085-580 São Luís, MA, Brazil.
  • Victor EC; School of Dentistry, Federal University of Maranhão, Avenida dos Portugueses, s/n, Campus Universitário do Bacanga, 65.085-580 São Luís, MA, Brazil.
  • Franco MM; School of Dentistry, Federal University of Maranhão, Avenida dos Portugueses, s/n, Campus Universitário do Bacanga, 65.085-580 São Luís, MA, Brazil.
  • Fernandes JM; Service Rheumatology of University Hospital, Federal University of Maranhão, Rua Barão de Itapari, 227 - Centro, São Luís, MA 65020-070, Brazil.
  • Maor Y; Phytor Lab for Drug Development, The Hadassah Medical Center Hebrew University Biotechnology Park (JBP), Ein Kerem Campus, Jerusalem 91120, Israel.
  • de Andrade MS; Department of Physiological Sciences, Federal University of Maranhão, Avenida dos Portugueses, s/n, Campus Universitário do Bacanga, 65.085-580 São Luís, MA, Brazil.
  • Rodrigues VP; School of Dentistry, Federal University of Maranhão, Avenida dos Portugueses, s/n, Campus Universitário do Bacanga, 65.085-580 São Luís, MA, Brazil.
  • Benatti BB; School of Dentistry, Federal University of Maranhão, Avenida dos Portugueses, s/n, Campus Universitário do Bacanga, 65.085-580 São Luís, MA, Brazil. Electronic address: bbbenatti@gmail.com.
Cytokine ; 85: 165-70, 2016 09.
Article em En | MEDLINE | ID: mdl-27371775
Both Systemic Lupus Erythematosus (SLE) and periodontal disease (PD) present a similar immunological profile mainly characterized by altered cytokine levels. In this study we sought to investigate the salivary levels of inflammatory cytokines and their association with PD in SLE patients. 60 patients with SLE and 54 systemically healthy individuals underwent a full periodontal clinical examination. They were then grouped according to their periodontal status. Stimulated saliva was collected in order to evaluate the salivary levels of interferon (IFN-γ), Interleukin (IL)-10, IL-17, IL-1ß, and IL-4. Systemically healthy individuals with periodontitis (group P) presented higher levels of cytokines when compared to systemically healthy individuals, with no periodontal disease (group S) (p<0.05). Additionally, in the P group, patients presented similar levels of cytokines to those of the patients with SLE, regardless of the presence of PD (p>0.05), for most of the analyzed cytokines. There was a positive correlation in SLE patients, including IL-1ß and all periodontal clinical parameters (p<0.05), and between IL-4 and gingival bleeding index and the presence of biofilm (p<0.05). Thus, our results confirmed, that patients with PD showed higher salivary levels of cytokines and, in SLE patients, the increased levels of salivary cytokines were observed even in the absence of periodontitis. IL-1ß and IL-4 salivary levels were also positively correlated with periodontal status indicating their potential as markers of the amount and extent of periodontal damage in patients with SLE.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Periodontais / Saliva / Citocinas / Inflamação / Lúpus Eritematoso Sistêmico Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cytokine Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Periodontais / Saliva / Citocinas / Inflamação / Lúpus Eritematoso Sistêmico Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cytokine Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido