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Human papillomavirus and lung cancinogenesis: an overview.
de Freitas, Antonio Carlos; Gurgel, Ana Pavla; de Lima, Elyda Golçalves; de França São Marcos, Bianca; do Amaral, Carolina Maria Medeiros.
Afiliação
  • de Freitas AC; Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Cidade Universitária, Av Professor Moraes Rêgo S/N, Recife, Pernambuco, 50670-901, Brazil. acf_ufpe@yahoo.com.br.
  • Gurgel AP; Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Cidade Universitária, Av Professor Moraes Rêgo S/N, Recife, Pernambuco, 50670-901, Brazil.
  • de Lima EG; Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Cidade Universitária, Av Professor Moraes Rêgo S/N, Recife, Pernambuco, 50670-901, Brazil.
  • de França São Marcos B; Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Cidade Universitária, Av Professor Moraes Rêgo S/N, Recife, Pernambuco, 50670-901, Brazil.
  • do Amaral CM; Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Cidade Universitária, Av Professor Moraes Rêgo S/N, Recife, Pernambuco, 50670-901, Brazil.
J Cancer Res Clin Oncol ; 142(12): 2415-2427, 2016 Dec.
Article em En | MEDLINE | ID: mdl-27357515
Lung cancer is the most common cause of cancer deaths worldwide. Although tobacco smoking is considered to be the main risk factor and the most well-established risk factor for lung cancer, a number of patients who do not smoke have developed this disease. This number varies between 15 % to over one-half of lung cancer cases, and the deaths from lung cancer in non-smokers are increasing every year. There are many other agents that are thought to be etiological, including diesel exhaust exposure, metals, radiation, radon, hormonal factors, cooking oil, air pollution and infectious diseases, such as human papillomavirus (HPV). Studies in various parts of the world have detected HPV DNA at different rates in lung tumors. However, the role of HPV in lung cancer is still unclear. Thus, in this review, we investigated some molecular mechanisms of HPV protein activity in host cells, the entry of HPV into lung tissue and the possible route used by the virus to reach the lung cells.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Transformação Celular Viral / Neoplasias Pulmonares Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Buscar no Google
Adicionar na Minha BVS
Imprimir
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PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Transformação Celular Viral / Neoplasias Pulmonares Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha