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Study of genetic diversity of killer cell immunoglobulin-like receptor loci in the Tujia ethnic minority.
Wang, Hong-Dan; Feng, Zhan-Qi; Shen, Chun-Mei; Guo, Qian-Nan; Dai, Peng-Fei; Zhang, Yu-Dang; Guo, Yu-Xin; Yan, Jiang-Wei; Zhu, Bo-Feng; Zhang, Li.
Afiliação
  • Wang HD; Medical Genetic Institute of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, PR China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, PR
  • Feng ZQ; Department of Urology, The First People's Hospital of Zhengzhou, Zhengzhou 450004, PR China.
  • Shen CM; Blood Center of Shaanxi Province, Xi'an 710061, PR China.
  • Guo QN; Medical Genetic Institute of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, PR China.
  • Dai PF; Department of Ophthalmology, Xi'an No. 4 Hospital, Guangren Hospital of Xi'an Jiaotong University, Xi'an 710004, PR China.
  • Zhang YD; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, PR China.
  • Guo YX; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, PR China.
  • Yan JW; Key Laboratory of Genome Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, PR China.
  • Zhu BF; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, PR China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710
  • Zhang L; Henan Red Cross Blood Center, Zhengzhou 450000, PR China. Electronic address: LILYZHL79@163.com.
Hum Immunol ; 77(10): 869-875, 2016 Oct.
Article em En | MEDLINE | ID: mdl-27343992
The aim of this study was to analyze the genetic profiles of 14 killer cell immunoglobulin-like receptor (KIR) genes and 2 pseudogenes of 124 individuals from Tujia ethnic minority residing in Enshi Tujia and Miao autonomous prefecture of Hubei province of China and investigate the genetic relationships between the Tujia ethnic minority and other reported groups for the first time. Sequence specific primer amplification (PCR-SSP) methods were used to genotype the 14 KIR genes and 2 pseudogenes. The observed carrier frequencies (OF) and the gene frequencies (GF) of the KIR genes were measured. Neighbor-joining (N-J) tree and the principal component analysis (PCA) plot were constructed. All individuals were typed positive for the three framework loci KIR3DL3, 2DL4 and 3DL2, as well as for pseudogene KIR3DP1. The gene frequencies of the other KIR genes ranged from 9% in KIR2DS2 to 98% in KIR2DP1 and KIR3DL1. The present study of the KIR genes may be a powerful tool for enriching the Chinese ethnical gene information resources of the KIR gene pool, as well as for the anthropological research.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Etnicidade / Pseudogenes / Receptores KIR Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Hum Immunol Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Etnicidade / Pseudogenes / Receptores KIR Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Hum Immunol Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos