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Effect of maternal supplementation with vitamin E on the concentration of α-tocopherol in colostrum.
Melo, Larisse Rayanne Miranda de; Clemente, Heleni Aires; Bezerra, Dalila Fernandes; Dantas, Raquel Costa Silva; Ramalho, Héryka Myrna Maia; Dimenstein, Roberto.
Afiliação
  • Melo LR; Universidade Federal do Rio Grande do Norte (UFRN), Departamento de Bioquímica, Natal, RN, Brazil.
  • Clemente HA; Universidade Federal do Rio Grande do Norte (UFRN), Departamento de Bioquímica, Natal, RN, Brazil.
  • Bezerra DF; Universidade Federal do Rio Grande do Norte (UFRN), Departamento de Bioquímica, Natal, RN, Brazil.
  • Dantas RC; Universidade Federal do Rio Grande do Norte (UFRN), Departamento de Bioquímica, Natal, RN, Brazil.
  • Ramalho HM; Universidade Potiguar (UnP), Departamento de Biotecnologia, Natal, RN, Brazil.
  • Dimenstein R; Universidade Federal do Rio Grande do Norte (UFRN), Departamento de Bioquímica, Natal, RN, Brazil. Electronic address: rdimenstein@gmail.com.
J Pediatr (Rio J) ; 93(1): 40-46, 2017.
Article em En | MEDLINE | ID: mdl-27327566
OBJECTIVE: To evaluate the effect of maternal supplementation with vitamin E on the concentration of α-tocopherol in colostrum and its supply to the newborn. METHOD: This randomized clinical trial enrolled 99 healthy adult pregnant women; of these, 39 were assigned to the control group and 60 to the supplemented group. After an overnight fast, 5mL of blood and 2mL of colostrum were collected. After the first sampling (0h milk), the supplemented group received 400IU of supplementary vitamin E. Another 2mL milk aliquot was collected in both groups 24h after supplementation (24h milk). The samples were analyzed by high-performance liquid chromatography. The α-tocopherol content provided by colostrum was calculated by considering a daily intake of 396mL of milk and comparing the resulting value to the recommended daily intake for infants aged 0-6 months (4mg/day). RESULTS: The initial mean concentration of α-tocopherol in colostrum was 1509.3±793.7µg/dL in the control group and 1452.9±808.6µg/dL in the supplemented group. After 24h, the mean α-tocopherol concentration was 1650.6±968.7µg/dL in the control group (p>0.05) and 2346.9±1203.2µg/dL in the supplemented group (p<0.001), increasing the vitamin E supply to the newborn to 9.3mg/day. Initially, 18 women in the supplemented group provided colostrum α-tocopherol contents below 4mg/day; after supplementation only six continued to provide less than the recommended amount. CONCLUSION: Maternal vitamin E supplementation increases the supply of the vitamin to the infant by providing more than twice the Recommended Daily Intake.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina E / Vitaminas / Colostro / Alfa-Tocoferol / Leite Humano Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Newborn Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina E / Vitaminas / Colostro / Alfa-Tocoferol / Leite Humano Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Newborn Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil