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Construction of a protein-protein interaction network of Wilms' tumor and pathway prediction of molecular complexes.
Teng, W J; Zhou, C; Liu, L J; Cao, X J; Zhuang, J; Liu, G X; Sun, C G.
Afiliação
  • Teng WJ; Shanghai Municipal Hospital of Traditional Chinese Medicine, Affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Zhou C; Cancer Center, WeiFang Traditional Chinese Hospital, Weifang, China.
  • Liu LJ; Cancer Center, WeiFang Traditional Chinese Hospital, Weifang, China.
  • Cao XJ; Clinical Institute, Shandong University of Traditional Chinese Medicine, Shandong, China.
  • Zhuang J; Cancer Center, WeiFang Traditional Chinese Hospital, Weifang, China.
  • Liu GX; Clinical Institute, Shandong University of Traditional Chinese Medicine, Shandong, China.
  • Sun CG; Cancer Center, WeiFang Traditional Chinese Hospital, Weifang, China.
Genet Mol Res ; 15(2)2016 May 23.
Article em En | MEDLINE | ID: mdl-27323086
Wilms' tumor (WT), or nephroblastoma, is the most common malignant renal cancer that affects the pediatric population. Great progress has been achieved in the treatment of WT, but it cannot be cured at present. Nonetheless, a protein-protein interaction network of WT should provide some new ideas and methods. The purpose of this study was to analyze the protein-protein interaction network of WT. We screened the confirmed disease-related genes using the Online Mendelian Inheritance in Man database, created a protein-protein interaction network based on biological function in the Cytoscape software, and detected molecular complexes and relevant pathways that may be included in the network. The results showed that the protein-protein interaction network of WT contains 654 nodes, 1544 edges, and 5 molecular complexes. Among them, complex 1 is predicted to be related to the Jak-STAT signaling pathway, regulation of hematopoiesis by cytokines, cytokine-cytokine receptor interaction, cytokine and inflammatory responses, and hematopoietic cell lineage pathways. Molecular complex 4 shows a correlation of WT with colorectal cancer and the ErbB signaling pathway. The proposed method can provide the bioinformatic foundation for further elucidation of the mechanisms of WT development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tumor de Wilms / Complexos Multiproteicos / Redes Reguladoras de Genes / Mapas de Interação de Proteínas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tumor de Wilms / Complexos Multiproteicos / Redes Reguladoras de Genes / Mapas de Interação de Proteínas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China País de publicação: Brasil