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Salivary Metabolite Fingerprint of Type 1 Diabetes in Young Children.
de Oliveira, Livia Roberta Piedade; Martins, Carla; Fidalgo, Tatiana Kelly Silva; Freitas-Fernandes, Liana Bastos; de Oliveira Torres, Rafaela; Soares, Aline Laignier; Almeida, Fabio C L; Valente, Ana Paula; de Souza, Ivete Pomarico Ribeiro.
Afiliação
  • de Oliveira LR; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro , 21941-971 Rio de Janeiro, RJ, Brazil.
  • Martins C; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro , 21941-971 Rio de Janeiro, RJ, Brazil.
  • Fidalgo TK; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro , 21941-971 Rio de Janeiro, RJ, Brazil.
  • Freitas-Fernandes LB; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro , 21941-971 Rio de Janeiro, RJ, Brazil.
  • de Oliveira Torres R; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro , 21941-971 Rio de Janeiro, RJ, Brazil.
  • Soares AL; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro , 21941-971 Rio de Janeiro, RJ, Brazil.
  • Almeida FC; National Center for Nuclear Magnetic Resonance - Jiri Jonas, Medical Biochemistry Institute, Federal University of Rio de Janeiro , 21.941-590 Rio de Janeiro, RJ, Brazil.
  • Valente AP; National Center for Nuclear Magnetic Resonance - Jiri Jonas, Medical Biochemistry Institute, Federal University of Rio de Janeiro , 21.941-590 Rio de Janeiro, RJ, Brazil.
  • de Souza IP; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro , 21941-971 Rio de Janeiro, RJ, Brazil.
J Proteome Res ; 15(8): 2491-9, 2016 08 05.
Article em En | MEDLINE | ID: mdl-27306956
Metabolomics is an important tool for the evaluation of the human condition, in both health or disease. This study analyzed the salivary components of type I diabetic children (DM1) under six years of age, to assess oral health related to diabetes control, as well as metabolite profiling using NMR. Partial least squared discriminant analysis (PLS-DA) was used to compare healthy (HG) and uncontrolled DM1 subjects that demonstrated a separation between the groups with classificatory performance of ACC = 0.80, R(2) = 0.92, Q(2) = 0.02 and for DM1 children with glycemia >200 mg/dL of ACC = 0.74, R(2) = 0.91, Q(2) = 0.06. The metabolites that mostly contributed to the distinction between the groups in the loading factor were acetate, n-acetyl-sugar, lactate, and sugar. The univariate analysis showed a decreased salivary concentration of succinic acid and increased levels of lactate, acetate, and sucrose in uncontrolled and DM1 children with glycemia >200 mg/dL. The present study demonstrates that the salivary profile of DM1 differs from that of HG children. It appears that diabetes status control has an important effect on the salivary composition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saliva / Diabetes Mellitus Tipo 1 / Metabolômica Tipo de estudo: Observational_studies Limite: Child, preschool / Humans Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saliva / Diabetes Mellitus Tipo 1 / Metabolômica Tipo de estudo: Observational_studies Limite: Child, preschool / Humans Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos