Your browser doesn't support javascript.
loading
Antibacterial properties and healing effects of Melipona scutellaris honey in MRSA-infected wounds of rats.
Medeiros, Vanessa de Fátima Lima Paiva; Azevedo, Ítalo Medeiros; Rêgo, Amália Cínthia Meneses; Egito, Eryvaldo Sócrates Tabosa do; Araújo-Filho, Irami; Medeiros, Aldo Cunha.
Afiliação
  • Medeiros Vde F; Fellow PhD degree, Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte (UFRN), Natal-RN, Brazil. Acquisition and interpretation of data, manuscript preparation., Universidade Federal do Rio Grande do Norte, Universidade Federal do Rio Grande do Norte, Natal RN , Braz
  • Azevedo ÍM; Fellow PhD degree, Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte (UFRN), Natal-RN, Brazil. Acquisition and interpretation of data, manuscript preparation., Universidade Federal do Rio Grande do Norte, Universidade Federal do Rio Grande do Norte, Natal RN , Braz
  • Rêgo AC; Associate Professor, Universidade Potiguar, Lauriate International Universities, Natal-RN, Brazil. Technical procedures, acquisition of data., Universidade Potiguar, Universidade Potiguar, Natal RN , Brazil.
  • Egito ES; Full Professor, Department of Fharmacy, UFRN, Natal-RN, Brazil. CNPq/PQ.1D fellowship. Analysis and interpretation of data, technical procedures, critical revision., Universidade Federal do Rio Grande do Norte, UFRN, Natal RN , Brazil.
  • Araújo-Filho I; PhD, Associate Professor, Nucleus of Experimental Surgery, Department of Surgery, UFRN, Natal-RN, Brazil. Analysis and interpretation of data, technical procedures, critical revision., Universidade Federal do Rio Grande do Norte, Nucleus of Experimental Surgery, Department of Surgery, UFRN, Natal RN
  • Medeiros AC; Full Professor, Chairman, Nucleus of Experimental Surgery, Department of Surgery, UFRN, Natal-RN, Brazil. CNPq/PQ.2 fellowship. Conception, design, intellectual and scientific content of the study; analysis and interpretation of data; technical procedures; critical revision., Universidade Federal do
Acta Cir Bras ; 31(5): 327-32, 2016 May.
Article em En | MEDLINE | ID: mdl-27275854
PURPOSE: To investigate the antimicrobial, immunological and healing effects of Melipona scutellaris honey on infected wounds of rat skin. METHODS: Twenty four Wistar rats were distributed in four groups (6-each). The uninfected skin wounds of group I rats were treated daily with saline for 7 days. Uninfected wounds (group II) rats were treated with honey. In group III (treated with saline) and group IV (treated with honey) wounds were inoculated with MRSA ATTC43300. The first bacterial culture was performed 24 hours later. In the 7th day new culture was done, and wound biopsies were used for cytokines dosage and histopathology. RESULTS: In group I and III rats the CFU/g count of S. aureus in wounds was zero. In group II rats the CFU/g counts in the wound tissue were significantly higher than in wounds of group IV rats. The density histopathological parameters and the expression of TNF-α, IL1-ß, Il-6 were significantly higher on wounds of group IV then in the other groups. CONCLUSION: Honey of Melipona scutellaris was effective in the management of infected wounds, by significant bacterial growth inhibition, enhancement of cytokine expression, and positively influenced the wound repair.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Cicatrização / Staphylococcus aureus Resistente à Meticilina / Apiterapia / Mel Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Cicatrização / Staphylococcus aureus Resistente à Meticilina / Apiterapia / Mel Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil