HTLV-1-associated myelopathy in a solid organ transplant recipient.
BMJ Case Rep
; 20162016 Jun 06.
Article
em En
| MEDLINE
| ID: mdl-27268291
Human T-cell lymphotropic virus type-1 (HTLV-1) is endemic in Japan, the Caribbean and in South American countries such as Ecuador. This virus is the cause of HTLV-1-associated myelopathy or tropical spastic paraparesis (HAM/TSP), a myelopathy characterised by chronic progressive paraparesis, spasticity and urinary symptoms. We report the case of a 40-year-old man who received a kidney transplant from a living donor and developed HAM/TSP, 24â
months after transplant. The diagnosis was confirmed by detection of HTLV-1 in blood and cerebrospinal fluid by the ELISA and Western Blot tests. For myelopathy, the patient was treated with pulse methylprednisolone, but had poor response to treatment. We recommend that all patients receiving transplants and their donors who come from endemic countries be given a mandatory screening for HTLV-1 through an ELISA test, in an effort to inform candidates for renal transplantation of the potential risk of infection and the development of this disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus Linfotrópico T Tipo 1 Humano
/
Paraparesia Espástica Tropical
/
Transplantados
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Ecuador
Idioma:
En
Revista:
BMJ Case Rep
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Equador
País de publicação:
Reino Unido