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Haematological recovery in poor and good haematopoietic stem cell mobilisers.
De Santis, G C; Garcia-Silva, A C; Chiaramonte, N C G; Orellana, M D; Prado, B P A; Oliveira, L C; Simões, B P; Covas, D T.
Afiliação
  • De Santis GC; Center for Cell-Based Therapy, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. gil@hemocentro.fmrp.usp.br.
  • Garcia-Silva AC; Center for Cell-Based Therapy, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
  • Chiaramonte NC; Center for Cell-Based Therapy, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
  • Orellana MD; Center for Cell-Based Therapy, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
  • Prado BP; Center for Cell-Based Therapy, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
  • Oliveira LC; Center for Cell-Based Therapy, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
  • Simões BP; Haematology Division, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
  • Covas DT; Center for Cell-Based Therapy, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Transfus Med ; 26(4): 297-300, 2016 Aug.
Article em En | MEDLINE | ID: mdl-27237104
OBJECTIVES: Evaluate whether poor mobilisers had delayed haematopoietic (neutrophil and platelet) recovery despite receiving similar cell dose as good mobilisers. BACKGROUND: Autologous haematopoietic progenitor cell (HPC) transplantation is indicated to treat some haematological malignancies. This procedure requires HPC mobilisation from bone marrow to peripheral blood. Cell dose is important for a fast haematological recovery. Despite being poor mobilisers, some patients can collect enough cell numbers for transplantation. RESULTS: Fifteen poor mobiliser patients (peak of CD34+ cells ≤10 µL(-1) in peripheral blood) were transplanted at our institution. Haematological recovery (neutrophil ≥ 500 µL(-1) ) in this group was compared to that observed in the group of 16 patients of good mobilisers (peak of CD34+ cells ≥20 µL(-1) in peripheral blood) who received similar cell dose (2·637 ± 0·1744 × 10(6) kg(-1) vs 2·727 ± 0·1746 × 10(6) kg(-1) ; P = 0·7177). The poor mobiliser group had neutrophil and platelet recovery later than the good mobiliser group (on day 12, range 9-14 vs day 10, range 9-22, P = 0·0381 for neutrophil, and on day 22·89 ± 11·16 and 14·08 ± 4·821, P = 0·0193 for platelet). Mortality rates and transfusion requirements were not different between the groups. CONCLUSION: Poor mobilisers have delayed neutrophil and platelet recovery after autologous HPC transplantation despite having received the same cell dose as good mobilisers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Neoplasias Hematológicas / Mobilização de Células-Tronco Hematopoéticas Tipo de estudo: Evaluation_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transfus Med Assunto da revista: HEMATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Neoplasias Hematológicas / Mobilização de Células-Tronco Hematopoéticas Tipo de estudo: Evaluation_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transfus Med Assunto da revista: HEMATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido