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Frequency of BKC-1-Producing Klebsiella Species Isolates.
Martins, Willames M B S; Nicoletti, Adriana G; Santos, Silvia R; Sampaio, Jorge L M; Gales, Ana C.
Afiliação
  • Martins WM; Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil willamesbrasileiro@hotmail.com.
  • Nicoletti AG; Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.
  • Santos SR; School of Pharmacy, University of São Paulo, São Paulo, Brazil.
  • Sampaio JL; School of Pharmacy, University of São Paulo, São Paulo, Brazil Fleury Diagnostic Medicine, Microbiology Section, São Paulo, Brazil.
  • Gales AC; Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.
Antimicrob Agents Chemother ; 60(8): 5044-6, 2016 08.
Article em En | MEDLINE | ID: mdl-27216068
BKC-1 is a new class A serine carbapenemase that was recently identified in Klebsiella pneumoniae clinical isolates. The principal objective of this study was to evaluate the frequency of blaBKC-1 by testing a collection of Klebsiella isolates. Only 2 of 635 Klebsiella isolates (0.3%) carried blaBKC-1 The two BKC-1-producing isolates belonged to clonal complex 442 and possessed identical pulsed-field gel electrophoresis patterns. The blaBKC-1 gene was inserted into a 10-kb plasmid that was identical to the previously reported plasmid, p60136. The BKC-producing K. pneumoniae isolates presented also possessed other mechanisms for beta-lactam resistance, such as genes encoding extended-spectrum beta-lactamases and mutations in the genes ompK35 and ompK36, encoding the major porins.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Beta-Lactamases / Klebsiella Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Beta-Lactamases / Klebsiella Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos