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Development and validation of a dissolution test for lutein tablets and evaluation of intestinal permeability.
Anselmo, Carina de Souza; Mendes, Thamara de Carvalho; Honorio, Thiago da Silva; do Carmo, Flávia Almada; Cabral, Lucio Mendes; de Sousa, Valeria Pereira.
Afiliação
  • Anselmo Cde S; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Mendes Tde C; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Honorio Tda S; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • do Carmo FA; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Cabral LM; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • de Sousa VP; Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: valeria@pharma.ufrj.br.
Food Chem ; 210: 63-9, 2016 Nov 01.
Article em En | MEDLINE | ID: mdl-27211621
Lutein is a carotenoid with antioxidant activity that is present in various dosage forms. The bioavailability of carotenoid from oral dosage formulations depends on their release, dissolution and its permeability through the gastrointestinal tract. Here, a dissolution test was developed for evaluating formulations and the bioavailability was assessed. The test utilized a USP-apparatus II with rotations of 50, 75 and 100rpm in water with P80 at 1, 2 and 5% (w/v). A non-everted rat intestinal sac model was used in conjunction to assess the intestinal permeability. The most discriminative conditions were 100rpm in water with 2% polysorbate 80, which showed profile differences between two formulations. The intestinal permeation studies showed a lag-time and apparent permeability coefficient that were characteristic of highly permeable drugs. We suggest that a dissolution test can be an essential quality control tool for formulations containing compounds as lutein, although not mandatory by the regulation agencies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mucosa Intestinal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Food Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mucosa Intestinal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Food Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido