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High prevalence of luminal B breast cancer intrinsic subtype in Colombian women.
Serrano-Gomez, Silvia Juliana; Sanabria-Salas, Maria Carolina; Hernández-Suarez, Gustavo; García, Oscar; Silva, Camilo; Romero, Alejandro; Mejía, Juan Carlos; Miele, Lucio; Fejerman, Laura; Zabaleta, Jovanny.
Afiliação
  • Serrano-Gomez SJ; Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
  • Sanabria-Salas MC; Programa de Doctorado en Ciencias Biologicas, Pontificia Universidad Javeriana, Bogota 110231, Colombia.
  • Hernández-Suarez G; Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
  • García O; Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
  • Silva C; Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
  • Romero A; Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
  • Mejía JC; Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
  • Miele L; Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
  • Fejerman L; Department of Genetics, LSUHSC, New Orleans, LA 70112, USA.
  • Zabaleta J; Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA 70112, USA.
Carcinogenesis ; 37(7): 669-676, 2016 07.
Article em En | MEDLINE | ID: mdl-27207651
Breast cancer is the most frequent malignancy in women worldwide. Distinct intrinsic subtypes of breast cancer have different prognoses, and their relative prevalence varies significantly among ethnic groups. Little is known about the prevalence of breast cancer intrinsic subtypes and their association with clinicopathological data and genetic ancestry in Latin Americans. Immunohistochemistry surrogates from the 2013 St. Gallen International Expert Consensus were used to classify breast cancers in 301 patients from Colombia into intrinsic subtypes. We analyzed the distribution of subtypes by clinicopathological variables. Genetic ancestry was estimated from a panel of 80 ancestry informative markers. Luminal B breast cancer subtype was the most prevalent in our population (37.2%) followed by luminal A (26.3%), non-basal triple negative (NBTN) (11.6%), basal like (9%), human epidermal growth factor receptor 2 (HER2) enriched (8.6%) and unknown (7.3%). We found statistical significant differences in distribution between Colombian region (P = 0.007), age at diagnosis (P = 0.0139), grade (P < 0.001) and recurrence (P < 0.001) according to intrinsic subtype. Patients diagnosed with HER2-enriched, basal-like and NBTN breast cancer had the highest African ancestry. Future studies analyzing the molecular profiles of breast cancer in Colombian women will help us understand the molecular basis of this subtype distribution and compare the molecular characteristics of the different intrinsic subtypes in Colombian patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prognóstico / Neoplasias da Mama / Biomarcadores Tumorais / Recidiva Local de Neoplasia Tipo de estudo: Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En Revista: Carcinogenesis Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prognóstico / Neoplasias da Mama / Biomarcadores Tumorais / Recidiva Local de Neoplasia Tipo de estudo: Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En Revista: Carcinogenesis Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido