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Effects of ozone therapy on facial nerve regeneration.
Ozbay, Isa; Ital, Ilker; Kucur, Cuneyt; Akcilar, Raziye; Deger, Aysenur; Aktas, Savas; Oghan, Fatih.
Afiliação
  • Ozbay I; Dumlupinar University, Department of Otolaryngology, Kutahya, Turkey. Electronic address: isaozbay@gmail.com.
  • Ital I; Dumlupinar University, Department of Anesthesiology and Reanimation, Kutahya, Turkey.
  • Kucur C; Dumlupinar University, Department of Otolaryngology, Kutahya, Turkey.
  • Akcilar R; Dumlupinar University, Department of Physiology, Kutahya, Turkey.
  • Deger A; Dumlupinar University, Department of Pathology, Kutahya, Turkey.
  • Aktas S; Mersin University, Department of Histology and Embryology, Mersin, Turkey.
  • Oghan F; Dumlupinar University, Department of Otolaryngology, Kutahya, Turkey.
Braz J Otorhinolaryngol ; 83(2): 168-175, 2017.
Article em En | MEDLINE | ID: mdl-27174776
INTRODUCTION: Ozone may promote moderate oxidative stress, which increases antioxidant endogenous systems. There are a number of antioxidants that have been investigated therapeutically for improving peripheral nerve regeneration. However, no previous studies have reported the effect of ozone therapy on facial nerve regeneration. OBJECTIVE: We aimed to evaluate the effect of ozone therapy on facial nerve regeneration. METHODS: Fourteen Wistar albino rats were randomly divided into two groups with experimental nerve crush injuries: a control group, which received saline treatment post-crush, and an experimental group, which received ozone treatment. All animals underwent surgery in which the left facial nerve was exposed and crushed. Treatment with saline or ozone began on the day of the nerve crush. Left facial nerve stimulation thresholds were measured before crush, immediately after crush, and after 30 days. After measuring nerve stimulation thresholds at 30 days post-injury, the crushed facial nerve was excised. All specimens were studied using light and electron microscopy. RESULTS: Post-crushing, the ozone-treated group had lower stimulation thresholds than the saline group. Although this did not achieve statistical significance, it is indicative of greater functional improvement in the ozone group. Significant differences were found in vascular congestion, macrovacuolization, and myelin thickness between the ozone and control groups. Significant differences were also found in axonal degeneration and myelin ultrastructure between the two groups. CONCLUSION: We found that ozone therapy exerted beneficial effect on the regeneration of crushed facial nerves in rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ozônio / Traumatismos do Nervo Facial / Regeneração Nervosa Limite: Animals Idioma: En Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ozônio / Traumatismos do Nervo Facial / Regeneração Nervosa Limite: Animals Idioma: En Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Brasil