Identification of mitochondrial DNA transfer in canine transmissible venereal tumours obtained from dogs in Mexico.
Mitochondrial DNA A DNA Mapp Seq Anal
; 28(5): 645-649, 2017 09.
Article
em En
| MEDLINE
| ID: mdl-27159723
Canine transmissible venereal tumour (CTVT) has been transmitted by cell transplantation from dog to dog, for over 10 000 years. Although initial studies report a single genetic origin for CTVT, recent samples from around the world reveal high genetic diversity. An elevated number of polymorphisms have been determined in mitochondrial DNA (mtDNA) of CTVT. The recent discovery of mtDNA transference from the host into tumoural cells could be a novel source of genetic diversity in CTVT. The aim of this study was to determine the presence of host mtDNA in samples of CTVT in Mexican dogs. Genotyping of 49 samples of CTVT and 49 samples of blood cells pertaining to affected dogs was performed by direct sequencing from the mtDNA D-loop region. Exogenous mtDNA was observed in 6% of the analysed tumours. This is the first investigation reporting the prevalence of exogenous mtDNA in CTVT in the Mexican dog population.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tumores Venéreos Veterinários
/
DNA Mitocondrial
/
Doenças do Cão
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Animals
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Mitochondrial DNA A DNA Mapp Seq Anal
Ano de publicação:
2017
Tipo de documento:
Article
País de publicação:
Reino Unido