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Effect of recombinant PDGF-BB on bone formation in the presence of ß-tricalcium phosphate and bovine bone mineral matrix: a pilot study in rat calvarial defects.
Luvizuto, Eloá R; Tangl, Stefan; Dobsak, Toni; Reich, Karoline; Gruber, Reinhard; Sonoda, Celso K; Okamoto, Roberta.
Afiliação
  • Luvizuto ER; Department of Surgery and Integrated Clinic, Araçatuba Dental School, UNESP-Univ Estadual Paulista, São Paulo, Brazil.
  • Tangl S; Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Division of Oral Surgery, Medical University of Vienna, Vienna, Austria.
  • Dobsak T; Austrian Cluster for Tissue Regeneration, Vienna, Austria.
  • Reich K; Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Division of Oral Surgery, Medical University of Vienna, Vienna, Austria.
  • Gruber R; Austrian Cluster for Tissue Regeneration, Vienna, Austria.
  • Sonoda CK; Karl Donath Laboratory for Hard Tissue and Biomaterial Research, Division of Oral Surgery, Medical University of Vienna, Vienna, Austria.
  • Okamoto R; Austrian Cluster for Tissue Regeneration, Vienna, Austria.
BMC Oral Health ; 16(1): 52, 2016 May 04.
Article em En | MEDLINE | ID: mdl-27145819
BACKGROUND: Supplementation of bone substitutes with recombinant platelet-derived growth factor-BB (PDGF-BB) can enhance bone regeneration. The aim of the study was to evaluate the effect of PDGF-BB on bone formation in the presence of ß-tricalcium phosphate and bovine bone mineral matrix in a rat calvaria defect model. METHODS: The authors examined 5 mm rat calvarial defects treated with ß-tricalcium phosphate (TCP) or demineralized bovine bone mineral (DBBM) with and without 0.3 mg/ml recombinant PDGF-BB. Calvaria defects were randomly divided into the following treatment groups (n = 5); TCP; TCP plus PDGF-BB; DBBM; DBBM plus PDGF-BB; and untreated empty control. After 45 days, bone formation was evaluated by histomorphometry and fluorescence microscopy. RESULTS: The authors report that the area of newly formed bone was similar between the empty controls and the two bone substitutes, TCP and DBBM. Supplementation of TCP and DBBM with PDGF-BB had no significant impact on bone formation. Fluorochrome staining revealed no visible changes in the pattern of bone formation in defects filled with TCP and DBBM, irrespective of PDGF-BB. Furthermore, supplementation with PDGF-BB did not influence biomaterial degradation. CONCLUSIONS: The authors concluded that PDGF-BB had no impact on bone formation and degradation of bone substitutes in the respective rodent models. Thus, possible beneficial effects of PDGF-BB may require other model situations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese / Fosfatos de Cálcio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: BMC Oral Health Assunto da revista: ODONTOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese / Fosfatos de Cálcio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: BMC Oral Health Assunto da revista: ODONTOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido