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Symptoms and Immune Markers in Plasmodium/Dengue Virus Co-infection Compared with Mono-infection with Either in Peru.
Halsey, Eric S; Baldeviano, G Christian; Edgel, Kimberly A; Vilcarromero, Stalin; Sihuincha, Moises; Lescano, Andres G.
Afiliação
  • Halsey ES; Virology Department, U.S. Naval Medical Research Unit No. 6, Lima and Iquitos, Peru.
  • Baldeviano GC; The President's Malaria Initiative, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
  • Edgel KA; Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
  • Vilcarromero S; Parasitology Department, U.S. Naval Medical Research Unit No. 6, Lima, Peru.
  • Sihuincha M; Parasitology Department, U.S. Naval Medical Research Unit No. 6, Lima, Peru.
  • Lescano AG; Virology Department, U.S. Naval Medical Research Unit No. 6, Lima and Iquitos, Peru.
PLoS Negl Trop Dis ; 10(4): e0004646, 2016 Apr.
Article em En | MEDLINE | ID: mdl-27128316
BACKGROUND: Malaria and dengue are two of the most common vector-borne diseases in the world, but co-infection is rarely described, and immunologic comparisons of co-infection with mono-infection are lacking. METHODOLOGY AND PRINCIPAL FINDINGS: We collected symptom histories and blood specimens from subjects in a febrile illness surveillance study conducted in Iquitos and Puerto Maldonado, Peru, between 2002-2011. Nineteen symptoms and 18 immune markers at presentation were compared among those with co-infection with Plasmodium/dengue virus (DENV), Plasmodium mono-infection, and DENV mono-infection. Seventeen subjects were identified as having Plasmodium/DENV co-infection and were retrospectively matched with 51 DENV mono-infected and 44 Plasmodium mono-infected subjects. Those with Plasmodium mono-infection had higher levels of IL-4, IL-6, IL-10, IL-12, IL-13, IL-17A, IFN-γ, and MIP1-α/CCL3 compared with DENV mono-infection or co-infection; those with Plasmodium mono-infection had more cough than those with DENV mono-infection. Subjects with DENV mono-infection had higher levels of TGF-ß1 and more myalgia than those with Plasmodium mono-infection. No symptom was more common and no immune marker level was higher in the co-infected group, which had similar findings to the DENV mono-infected subjects. CONCLUSIONS/SIGNIFICANCE: Compared with mono-infection with either pathogen, Plasmodium/DENV co-infection was not associated with worse disease and resembled DENV mono-infection in both symptom frequency and immune marker level.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Dengue / Coinfecção / Malária Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Peru Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Peru País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Dengue / Coinfecção / Malária Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Peru Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Peru País de publicação: Estados Unidos