Prolonged activation of human islet cannabinoid receptors in vitro induces adaptation but not dysfunction.

Vilches-Flores, Alonso; Franklin, Zara; Hauge-Evans, Astrid C; Liu, Bo; Huang, Guo C; Choudhary, Pratik; Jones, Peter M; Persaud, Shanta J

Vilches-Flores, Alonso; Franklin, Zara; Hauge-Evans, Astrid C; Liu, Bo; Huang, Guo C; Choudhary, Pratik; Jones, Peter M; Persaud, Shanta J.

Afiliação

Vilches-Flores A; Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, UK; Universidad Nacional Autonoma de Mexico, FES Iztacala, Mexico.
Franklin Z; Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, UK.
Hauge-Evans AC; Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, UK; Department of Life Sciences, University of Roehampton, London, UK.
Liu B; Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, UK.
Huang GC; Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, UK.
Choudhary P; Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, UK.
Jones PM; Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, UK.
Persaud SJ; Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, UK.

BBA Clin ; 5: 143-50, 2016 Jun.

Article em En | MEDLINE | ID: mdl-27114924

Palavras-chave

2-AG, 2-arachidonoyl glycerol; ACEA, N-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eiscosatetraenamide; AEA, anandamide; Apoptosis; CB1r, cannabinoid receptor type 1; CB2r, cannabinoid receptor type 2; DAGL, diacylglycerol lipase; ECS, endocannabinoid system; Endocannabinoid system; FAAH, fatty acid amide hydrolase; Gene expression; Glucagon; Human islets; Insulin; JWH015, (2-methyl-1propyl-1H-indol-3-yl)-1-napthalenylmethanone; MAGL, monoacylglycerol lipase; NAPE-PLD, N-acyl-phosphatidyl ethanolamide-hydrolysing phospholipase D; PPG, preproglucagon; PPI, preproinsulin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: BBA Clin Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Holanda

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