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Biflorin induces cytotoxicity by DNA interaction in genetically different human melanoma cell lines.
Ralph, Ana Carolina Lima; Calcagno, Danielle Queiroz; da Silva Souza, Luciana Gregório; de Lemos, Telma Leda Gomes; Montenegro, Raquel Carvalho; de Arruda Cardoso Smith, Marília; de Vasconcellos, Marne Carvalho.
Afiliação
  • Ralph ACL; Pharmaceutical Sciences, Federal University of Amazon, Av. General Rodrigo Octávio, 6200, Coroado, 69077-000 Manaus, Amazonas, Brazil; Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Rua Alexandre Amorim, 330, Aparecida, CEP: 69010-300, Manaus, Amazonas, Brazil.
  • Calcagno DQ; Center on Oncology Research, Federal University of Pará, PA, Brazil; Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Av. Mundurucus, 4487, Guamá, 66073-000, Belém, PA, Brazil. Electronic address: danicalcagno@gmail.com.
  • da Silva Souza LG; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Ceará, Brazil. Electronic address: luci.gregorio@yahoo.com.br.
  • de Lemos TLG; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Ceará, Brazil. Electronic address: tlemos@dqoi.ufc.br.
  • Montenegro RC; Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Av. Mundurucus, 4487, Guamá, 66073-000, Belém, PA, Brazil. Electronic address: rcm.montenegro@gmail.com.
  • de Arruda Cardoso Smith M; Genetic Division, Federal University of São Paulo, Rua Botucatu 740, Vila Clementino, 04023-062 São Paulo, SP, Brazil; Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, Rua Botucatu 740, Vila Clementino, 04023-062 São Paulo, SP, Brazil. Electronic addr
  • de Vasconcellos MC; Pharmaceutical Sciences, Federal University of Amazon, Av. General Rodrigo Octávio, 6200, Coroado, 69077-000 Manaus, Amazonas, Brazil; Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Av. General Rodrigo Octávio 6200, Coroado I, 69077-000 Manaus, Amazonas, Brazil. Electronic ad
Toxicol In Vitro ; 34: 237-245, 2016 Aug.
Article em En | MEDLINE | ID: mdl-27079618
Cancer is a public health problem and the second leading cause of death worldwide. The incidence of cutaneous melanoma has been notably increasing, resulting in high aggressiveness and poor survival rates. Taking into account the antitumor activity of biflorin, a substance isolated from Capraria biflora L. roots that is cytotoxic in vitro and in vivo, this study aimed to demonstrate the action of biflorin against three established human melanoma cell lines that recapitulate the molecular landscape of the disease in terms of genetic alterations and mutations, such as the TP53, NRAS and BRAF genes. The results presented here indicate that biflorin reduces the viability of melanoma cell lines by DNA interactions. Biflorin causes single and double DNA strand breaks, consequently inhibiting cell cycle progression, replication and DNA repair and promoting apoptosis. Our data suggest that biflorin could be considered as a future therapeutic option for managing melanoma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Naftoquinonas / Melanoma Limite: Humans Idioma: En Revista: Toxicol In Vitro Assunto da revista: TOXICOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Naftoquinonas / Melanoma Limite: Humans Idioma: En Revista: Toxicol In Vitro Assunto da revista: TOXICOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido