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Molecular epidemiology of Trypanosoma cruzi and Triatoma dimidiata in costal Ecuador.
Wong, Yim Yan; Sornosa Macias, Karen Jeniffer; Guale Martínez, Doris; Solorzano, Luis F; Ramirez-Sierra, Maria Jesus; Herrera, Claudia; Dumonteil, Eric.
Afiliação
  • Wong YY; Centro de Referencia Nacional de Parasitología, Instituto Nacional de Investigación en Salud Pública Leopoldo Izquieta Perez (INSPI), Guayaquil, Ecuador.
  • Sornosa Macias KJ; Centro de Referencia Nacional de Parasitología, Instituto Nacional de Investigación en Salud Pública Leopoldo Izquieta Perez (INSPI), Guayaquil, Ecuador.
  • Guale Martínez D; Centro de Referencia Nacional de Parasitología, Instituto Nacional de Investigación en Salud Pública Leopoldo Izquieta Perez (INSPI), Guayaquil, Ecuador.
  • Solorzano LF; Centro de Referencia Nacional de Parasitología, Instituto Nacional de Investigación en Salud Pública Leopoldo Izquieta Perez (INSPI), Guayaquil, Ecuador.
  • Ramirez-Sierra MJ; Laboratorio de Parasitología, Centro de Investigaciones Regionales "Hideyo Noguchi", Universidad Autónoma de Yucatán, Merida, Yucatan, Mexico.
  • Herrera C; Department of Tropical Medicine, Vector-Borne Infection Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
  • Dumonteil E; Centro de Referencia Nacional de Parasitología, Instituto Nacional de Investigación en Salud Pública Leopoldo Izquieta Perez (INSPI), Guayaquil, Ecuador; Laboratorio de Parasitología, Centro de Investigaciones Regionales "Hideyo Noguchi", Universidad Autónoma de Yucatán, Merida, Yucatan, Mexico; Dep
Infect Genet Evol ; 41: 207-212, 2016 07.
Article em En | MEDLINE | ID: mdl-27079265
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. In Ecuador, Triatoma dimidiata and Rhodnius ecuadoriensis are the main vector species, responsible for over half of the cases of T. cruzi infection in the country. T. dimidiata is believed to have been introduced in Ecuador during colonial times, and its elimination from the country is thus believed to be feasible. We investigated here the molecular ecology of T. dimidiata and T. cruzi in costal Ecuador to further guide control efforts. Analysis of the Internal Transcribed Spacer 2 (ITS-2) of 23 specimens from Progreso, Guayas, unambiguously supported the likely importation of T. dimidiata from Central America to Ecuador. The observation of a very high parasite infection rate (54%) and frequent feeding on humans (3/5) confirmed a continued risk of transmission to humans. All genotyped parasites corresponded to TcI DTU and Trypanosoma rangeli was not detected in T. dimidiata. TcI subgroups corresponded to TcIa (25%), and mixed infections with TcIa and TcId (75%). Further studies should help clarify T. cruzi genetic structure in the country, and the possible impact of the introduction of T. dimidiata on the circulating parasite strains. The elevated risk posed by this species warrants continuing efforts for its control, but its apparent mobility between peridomestic and domestic habitats may favor reinfestation following insecticide spraying.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Triatoma / Doença de Chagas / DNA Intergênico / Espécies Introduzidas / Estágios do Ciclo de Vida Tipo de estudo: Prognostic_studies / Screening_studies Limite: Animals / Female / Humans / Male País/Região como assunto: America do sul / Ecuador Idioma: En Revista: Infect Genet Evol Assunto da revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Equador País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Triatoma / Doença de Chagas / DNA Intergênico / Espécies Introduzidas / Estágios do Ciclo de Vida Tipo de estudo: Prognostic_studies / Screening_studies Limite: Animals / Female / Humans / Male País/Região como assunto: America do sul / Ecuador Idioma: En Revista: Infect Genet Evol Assunto da revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Equador País de publicação: Holanda