Your browser doesn't support javascript.
loading
Preventive and therapeutic moderate aerobic exercise programs convert atherosclerotic plaques into a more stable phenotype.
Cardinot, Themis M; Lima, Thais M; Moretti, Ana I S; Koike, Marcia K; Nunes, Valeria S; Cazita, Patricia M; Krieger, Marta H; Brum, Patricia C; Souza, Heraldo P.
Afiliação
  • Cardinot TM; Emergency Medicine Department (LIM-51), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Lima TM; Emergency Medicine Department (LIM-51), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. Electronic address: thais@emercli.fm.usp.br.
  • Moretti AI; Emergency Medicine Department (LIM-51), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Koike MK; Emergency Medicine Department (LIM-51), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Nunes VS; Lipids Laboratory (LIM-10), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Cazita PM; Lipids Laboratory (LIM-10), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Krieger MH; Department of Physiology and Biophysics, Institute of Biology, State University of Campinas, Campinas, SP, Brazil.
  • Brum PC; School of Physical Education and Sports, Universidade de São Paulo, São Paulo, Brazil.
  • Souza HP; Emergency Medicine Department (LIM-51), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Life Sci ; 153: 163-70, 2016 May 15.
Article em En | MEDLINE | ID: mdl-27074350
UNLABELLED: The mechanisms by which exercise affects atherosclerotic plaque stability remain incompletely understood. We evaluated the effects of two training protocols on both atherosclerotic plaque structure and the signaling pathways involved in plaque rupture. METHODS: Male low-density lipoprotein (LDL) receptor knockout mice were fed a high-fat, high-cholesterol diet (HFD). One group was subjected to moderate exercise using a treadmill for 14weeks (preventive protocol). The other group started an exercise regimen after 16weeks of the HFD (therapeutic group). Atherosclerotic plaques within the aorta were evaluated for lipid and collagen contents, as well as for inflammatory markers. Plasma cholesterol and cytokine levels were also determined. RESULTS: The mice receiving a HFD developed hypercholesterolemia and atherosclerotic plaques within the aorta. The aortas from the animals in the preventive protocol exhibited smaller lipid cores and higher collagen content. These animals also exhibited lower CD40 expression within the plaques. The aortas of the mice in the therapeutic group exhibited higher collagen content, but no differences in either lipid core size or plaque size were noted. No differences in blood pressure, plasma cholesterol, cytokine levels, plaque size or metalloproteinase 9 expression were observed in the trained animals compared with the sedentary animals. CONCLUSION: Moderate aerobic exercise modified atherosclerotic plaque characteristics and converted the plaques into a more stable phenotype, increasing the collagen content in response to both exercise programs. Furthermore, moderate aerobic exercise reduced the animals' fat content and decreased the activity of the CD40-CD40L signaling pathway in the preventive group.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Placa Aterosclerótica Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Placa Aterosclerótica Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda