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Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer.
Souza, Ana Carolina Flygare; DA Silva, Victor Hugo Pereira; Seixas, Camila; DE Oliveira Scudeller, Tania Terezinha; DO Amaral, Maria Teresa Pace; Ribeiro, Daniel Araki.
Afiliação
  • Souza AC; Department of Biosciences, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
  • DA Silva VH; Department of Biosciences, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
  • Seixas C; Department of Biosciences, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
  • DE Oliveira Scudeller TT; Department of Management and Health Care, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
  • DO Amaral MT; Department of Management and Health Care, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
  • Ribeiro DA; Department of Biosciences, Federal University of Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil daribeiro@unifesp.br daribeiro@pesquisador.cnpq.br.
Anticancer Res ; 36(4): 1955-8, 2016 Apr.
Article em En | MEDLINE | ID: mdl-27069186
In addition to surgery, one of the most widely applied treatments for breast cancer is chemotherapy. Chemotherapy is currently considered efficient in curing this disease; however, the therapy may induce damage to the patient's genetic material. Thus, the aim of this study was to evaluate putative cytotoxic and mutagenic effects induced by chemotherapy in women diagnosed with breast cancer. For this purpose, a cross-sectional study was carried out in 42 women, aged 18 to 70 years, allocated according to the diagnosis and stage of breast cancer treatment: control group (healthy) (n=15), chemotherapy group (n=11) and post-chemotherapy group (n=16). Cytotoxicity and mutagenicity were analyzed by the micronucleus test in buccal mucosa cells. A higher frequency (p<0.05) of micronucleated cells was detected in the chemotherapy and post-chemotherapy groups when compared to the control. A higher frequency (p<0.05) of karyorrhexis and pyknosis in the chemotherapy group was also noted. Taken together, our results indicate that chemotherapy induces mutagenicity and cytotoxicity in buccal mucosa cells of women diagnosed with breast cancer, being persistent after finishing their treatment.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Ductal de Mama / Micronúcleos com Defeito Cromossômico / Mucosa Bucal / Antineoplásicos Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Grécia
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Ductal de Mama / Micronúcleos com Defeito Cromossômico / Mucosa Bucal / Antineoplásicos Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Grécia