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Sex Differences in High Sensitivity C-Reactive Protein in Subjects with Risk Factors of Metabolic Syndrome.
Garcia, Vinicius Pacheco; Rocha, Helena Naly Miguens; Sales, Allan Robson Kluser; Rocha, Natália Galito; da Nóbrega, Antonio Claudio Lucas.
Afiliação
  • Garcia VP; Departamento de Fisiologia e Farmacologia, Laboratório de Ciências do Exercício, Universidade Federal Fluminense, Niterói, RJ, Brazil.
  • Rocha HN; Departamento de Fisiologia e Farmacologia, Laboratório de Ciências do Exercício, Universidade Federal Fluminense, Niterói, RJ, Brazil.
  • Sales AR; Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
  • Rocha NG; Departamento de Fisiologia e Farmacologia, Laboratório de Ciências do Exercício, Universidade Federal Fluminense, Niterói, RJ, Brazil.
  • da Nóbrega AC; Departamento de Fisiologia e Farmacologia, Laboratório de Ciências do Exercício, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Arq Bras Cardiol ; 106(3): 182-7, 2016 Mar.
Article em En, Pt | MEDLINE | ID: mdl-27027366
BACKGROUND: Metabolic syndrome (MetS) is associated with a higher risk of all-cause mortality. High-sensitivity C-reactive protein (hsCRP) is a prototypic marker of inflammation usually increased in MetS. Women with MetS-related diseases present higher hsCRP levels than men with MetS-related diseases, suggesting sex differences in inflammatory markers. However, it is unclear whether serum hsCRP levels are already increased in men and/or women with MetS risk factors and without overt diseases or under pharmacological treatment. OBJECTIVE: To determine the impact of the number of MetS risk factors on serum hsCRP levels in women and men. Methods One hundred and eighteen subjects (70 men and 48 women; 36 ± 1 years) were divided into four groups according to the number of MetS risk factors: healthy group (CT; no risk factors), MetS ≤ 2, MetS = 3, and MetS ≥ 4. Blood was drawn after 12 hours of fasting for measurement of biochemical variables and hsCRP levels, which were determined by immunoturbidimetric assay. RESULTS: The groups with MetS risk factors presented higher serum hsCRP levels when compared with the CT group (p < 0.02). There were no differences in hsCRP levels among groups with MetS risk factors (p > 0.05). The best linear regression model to explain the association between MetS risk factors and hsCRP levels included waist circumference and HDL cholesterol (r = 0.40, p < 0.01). Women with MetS risk factors presented higher hsCRP levels when compared with men (p sex < 0.01). CONCLUSIONS: Despite the absence of overt diseases and pharmacological treatment, subjects with MetS risk factors already presented increased hsCRP levels, which were significantly higher in women than men at similar conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Fatores Sexuais / Síndrome Metabólica Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Fatores Sexuais / Síndrome Metabólica Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil