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Adipose-Derived Stem Cells as a Tool for Dental Implant Osseointegration: an Experimental Study in the Dog.
Bressan, Eriberto; Botticelli, Daniele; Sivolella, Stefano; Bengazi, Franco; Guazzo, Riccardo; Sbricoli, Luca; Ricci, Sara; Ferroni, Letizia; Gardin, Chiara; Velez, Joaquin Urbizo; Zavan, Barbara.
Afiliação
  • Bressan E; Department of Neurosciences, University of Padua, Padua, Italy.; Faculty of Dentistry, University of Medical Science, La Habana, Cuba.
  • Botticelli D; Faculty of Dentistry, University of Medical Science, La Habana, Cuba.; Oral Surgery Division, ARDEC, Ariminum Odontologica, Rimini, Italy.
  • Sivolella S; Department of Neurosciences, University of Padua, Padua, Italy.; Faculty of Dentistry, University of Medical Science, La Habana, Cuba.
  • Bengazi F; Faculty of Dentistry, University of Medical Science, La Habana, Cuba.
  • Guazzo R; Department of Neurosciences, University of Padua, Padua, Italy.
  • Sbricoli L; Department of Neurosciences, University of Padua, Padua, Italy.
  • Ricci S; Department of Neurosciences, University of Padua, Padua, Italy.
  • Ferroni L; Department of Neurosciences, University of Padua, Padua, Italy.
  • Gardin C; Department of Biomedical Sciences, University of Padua, Via Bassi 58, 35100 Padua, Italy.
  • Velez JU; Faculty of Dentistry, University of Medical Science, La Habana, Cuba.
  • Zavan B; Department of Biomedical Sciences, University of Padua, Via Bassi 58, 35100 Padua, Italy.
Int J Mol Cell Med ; 4(4): 197-208, 2015.
Article em En | MEDLINE | ID: mdl-27014644
The biological interaction between the jaw bones and dental implant is fundamental for the long-term success of dental implant placement. Nevertheless, the insufficient bone volume remains a major clinical problem, especially in case of immediate dental implant. Using a canine model, the present study proves the regenerative potential of adipose- derived stem cells (ADSCs) to repair peri-implant bone defects occurring in immediate dental implant placement. In six labradors, all mandibular premolars and the first molars were extracted bilaterally and three months later dental implants were installed with a marginal gap. The marginal defects were filled with hydroxyapatite (HA)-based scaffolds previously seeded with ADSCs. After one month of healing, specimens were prepared for histological and histomorphometric evaluations. Histological analyses of ground sections show that ADSCs significantly increase bone regeneration. Several new vessels, osteoblasts and new bone matrix were detected. By contrast, no inflammatory cells have been revealed. ADSCs could be used to accelerate bone healing in peri- implant defects in case of immediate dental implant placement.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Mol Cell Med Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Cuba País de publicação: Irã
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Mol Cell Med Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Cuba País de publicação: Irã