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EVALUATION OF THE EXTRACELLULAR MATRIX OF INJURED SUPRASPINATUS IN RATS.
Almeida, Luiz Henrique Oliveira; Ikemoto, Roberto; Mader, Ana Maria; Pinhal, Maria Aparecida Silva; Munhoz, Bruna; Murachovsky, Joel.
Afiliação
  • Almeida LH; Faculdade de Medicina do ABC, Santo André, SP, Brazil.
  • Ikemoto R; Faculdade de Medicina do ABC, Santo André, SP, Brazil.
  • Mader AM; Faculdade de Medicina do ABC, Santo André, SP, Brazil.
  • Pinhal MA; Faculdade de Medicina do ABC, Santo André, SP, Brazil.
  • Munhoz B; Faculdade de Medicina do ABC, Santo André, SP, Brazil.
  • Murachovsky J; Faculdade de Medicina do ABC, Santo André, SP, Brazil.
Acta Ortop Bras ; 24(1): 11-5, 2016.
Article em En | MEDLINE | ID: mdl-26997907
OBJECTIVE: To evaluate the evolution of injuries of the supraspinatus muscle by immunohistochemistry (IHC) and anatomopathological analysis in animal model (Wistar rats). METHODS: Twenty-five Wistar rats were submitted to complete injury of the supraspinatus tendon, then subsequently sacrificed in groups of five animals at the following periods: immediately after the injury, 24h after the injury, 48h after, 30 days after and three months after the injury. All groups underwent histological and IHC analysis. RESULTS: Regarding vascular proliferation and inflammatory infiltrate, we found a statistically significant difference between groups 1(control group) and 2 (24h after injury). IHC analysis showed that expression of vascular endothelial growth factor (VEGF) showed a statistically significant difference between groups 1 and 2, and collagen type 1 (Col-1) evaluation presented a statistically significant difference between groups 1 and 4. CONCLUSION: We observed changes in the extracellular matrix components compatible with remodeling and healing. Remodeling is more intense 24h after injury. However, VEGF and Col-1 are substantially increased at 24h and 30 days after the injury, respectively. Level of Evidence I, Experimental Study.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Acta Ortop Bras Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Acta Ortop Bras Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil