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Antioxidant, antimutagenic and antiproliferative activities in selected seaweed species from Sinaloa, Mexico.
Osuna-Ruiz, Idalia; López-Saiz, Carmen-María; Burgos-Hernández, Armando; Velázquez, Carlos; Nieves-Soto, Mario; Hurtado-Oliva, Miguel A.
Afiliação
  • Osuna-Ruiz I; a Facultad De Ciencias Del Mar , Universidad Autónoma De Sinaloa , Mazatlán , Sinaloa , México ;
  • López-Saiz CM; b Departamento De Investigación Y Posgrado En Alimentos , Universidad De Sonora , Sonora , México ;
  • Burgos-Hernández A; b Departamento De Investigación Y Posgrado En Alimentos , Universidad De Sonora , Sonora , México ;
  • Velázquez C; c Departamento De Ciencias Químico Biológicas , Universidad De Sonora , Sonora , México.
  • Nieves-Soto M; a Facultad De Ciencias Del Mar , Universidad Autónoma De Sinaloa , Mazatlán , Sinaloa , México ;
  • Hurtado-Oliva MA; a Facultad De Ciencias Del Mar , Universidad Autónoma De Sinaloa , Mazatlán , Sinaloa , México ;
Pharm Biol ; 54(10): 2196-210, 2016 Oct.
Article em En | MEDLINE | ID: mdl-26959892
Context Seaweeds from the Mexican Pacific Ocean have not been evaluated as a source of chemoprotectants. Objective The objective of this study is to evaluate chemopreventive activities of the seaweeds Phaephyceae - Padina durvillaei (Dictyotaceae) - Rodhophyceae - Spyridia filamentosa (Spyridiaceae), Gracilaria vermiculophylla (Gracilariaceae) - and Chlorophyceae - Ulva expansa (Ulvaceae), Codium isabelae (Codiaceae), Rhizoclonium riparium (Cladophoraceae) and Caulerpa sertularioides (Caulerpaceae). Materials and methods Methanol, acetone and hexane seaweed extracts were assessed at 30 and 3 mg/mL on antioxidant capacity (DPPH and ABTS assays), 0.003-3.0 mg/plate on antimutagenic activity against AFB1 using Salmonella typhimurium TA98 and TA100 tester strains in Ames test, and 12.5 to 100 µg/mL on antiproliferative activity on Murine B-cell lymphoma. Phenols, flavonoids and pigments content were also assessed as antioxidant compounds. Results Extraction yield was higher in methanol than in acetone and hexane extracts (6.4, 2.7 and 1.4% dw). Antioxidant capacity was higher in brown and green than in red seaweed species, particularly in P. durvillaei extracted in acetone (EC50 value= 16.9 and 1.56 mg/mL for DPPH and ABTS). Flavonoids and chlorophylls were identified as mainly antioxidant components; particularly in hexane extracts, which were correlated with the antioxidant capacity. Highest mutagenesis inhibition (> 40%) occurred in R. riparium at the lowest concentration assayed (0.003 mg/plate), while highest antiproliferative inhibition (37 and 72% for 12.5 and 25 µg/mL) occurred in C. sertularioides. Discussion and conclusion Flavonoids and chlorophylls explained the chemopreventive activities assessed in S. filamentosa, R. riparium and C. sertularioides. These seaweeds have a high potential as a source of novel chemoprotectants.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antimutagênicos / Proliferação de Células / Mutação / Antineoplásicos / Antioxidantes Limite: Animals País/Região como assunto: Mexico Idioma: En Revista: Pharm Biol Ano de publicação: 2016 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antimutagênicos / Proliferação de Células / Mutação / Antineoplásicos / Antioxidantes Limite: Animals País/Região como assunto: Mexico Idioma: En Revista: Pharm Biol Ano de publicação: 2016 Tipo de documento: Article País de publicação: Reino Unido