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Maternal vitamin B6 deficient or supplemented diets on expression of genes related to GABAergic, serotonergic, or glutamatergic pathways in hippocampus of rat dams and their offspring.
Almeida, Mara Ribeiro; Mabasa, Lawrence; Crane, Courtney; Park, Chung S; Venâncio, Vinícius Paula; Bianchi, Maria Lourdes Pires; Antunes, Lusânia Maria Greggi.
Afiliação
  • Almeida MR; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
  • Mabasa L; Department of Animal Sciences, North Dakota State University, Fargo, North Dakota, USA.
  • Crane C; Department of Animal Sciences, North Dakota State University, Fargo, North Dakota, USA.
  • Park CS; Department of Animal Sciences, North Dakota State University, Fargo, North Dakota, USA.
  • Venâncio VP; Department of Animal Sciences, North Dakota State University, Fargo, North Dakota, USA.
  • Bianchi ML; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
  • Antunes LM; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Mol Nutr Food Res ; 60(7): 1615-24, 2016 07.
Article em En | MEDLINE | ID: mdl-26935476
SCOPE: Vitamin B6 plays crucial roles on brain development and its maternal deficiency impacts the gamma-aminobutyric acid (GABA)ergic, serotonergic, glutamatergic, and dopaminergic systems in offspring. However, the molecular mechanisms underlying these neurological changes are not well understood. Thus, we aimed at evaluating which components of those neurotransmitter metabolism and signaling pathways can be modulated by maternal vitamin B6 -deficient or B6 -supplementated diets in the hippocampus of rat dams and their offspring. METHODS AND RESULTS: Female Wistar rats were fed three different diets: control (6 mg vitamin B6 /kg), supplemented (30 mg vitamin B6 /kg) or deficient diet (0 mg vitamin B6 /kg), from 4 weeks before pregnancy through lactation. Newborn pups (10 days old) from rat dams fed vitamin B6 -deficient diet presented hyperhomocysteinemia and had a significant increase in mRNA levels of glutamate decarboxylase 1 (Gad1), fibroblast growth factor 2 (Fgf2), and glutamate-ammonia ligase (Glul), while glutaminase (Gls) and tryptophan hydroxylase 1 (Tph1) mRNAs were downregulated. Vitamin B6 supplementation or deficiency did not change hippocampal global DNA methylation. CONCLUSION: A maternal vitamin B6 -deficient diet affects the expression of genes related to GABA, glutamate, and serotonin metabolisms in offspring by regulating Gad1, Glul, Gls, and Tph1 mRNA expression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Vitamina B 6 / Vitamina B 6 / Hipocampo Limite: Animals Idioma: En Revista: Mol Nutr Food Res Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Vitamina B 6 / Vitamina B 6 / Hipocampo Limite: Animals Idioma: En Revista: Mol Nutr Food Res Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha