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A review of solute encapsulating nanoparticles used as delivery systems with emphasis on branched amphipathic peptide capsules.
Barros, Sheila M; Whitaker, Susan K; Sukthankar, Pinakin; Avila, L Adriana; Gudlur, Sushanth; Warner, Matt; Beltrão, Eduardo I C; Tomich, John M.
Afiliação
  • Barros SM; Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA; Department of Biochemistry, Federal University of Pernambuco-UFPE, Recife, Pernambuco, 50670-901, Brazil.
  • Whitaker SK; Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA.
  • Sukthankar P; Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA.
  • Avila LA; Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA.
  • Gudlur S; Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA.
  • Warner M; Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA.
  • Beltrão EI; Department of Biochemistry, Federal University of Pernambuco-UFPE, Recife, Pernambuco, 50670-901, Brazil.
  • Tomich JM; Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA. Electronic address: jtomich@ksu.edu.
Arch Biochem Biophys ; 596: 22-42, 2016 04 15.
Article em En | MEDLINE | ID: mdl-26926258
Various strategies are being developed to improve delivery and increase the biological half-lives of pharmacological agents. To address these issues, drug delivery technologies rely on different nano-sized molecules including: lipid vesicles, viral capsids and nano-particles. Peptides are a constituent of many of these nanomaterials and overcome some limitations associated with lipid-based or viral delivery systems, such as tune-ability, stability, specificity, inflammation, and antigenicity. This review focuses on the evolution of bio-based drug delivery nanomaterials that self-assemble forming vesicles/capsules. While lipid vesicles are preeminent among the structures; peptide-based constructs are emerging, in particular peptide bilayer delimited capsules. The novel biomaterial-Branched Amphiphilic Peptide Capsules (BAPCs) display many desirable properties. These nano-spheres are comprised of two branched peptides-bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK, designed to mimic diacyl-phosphoglycerides in molecular architecture. They undergo supramolecular self-assembly and form solvent-filled, bilayer delineated capsules with sizes ranging from 20 nm to 2 µm depending on annealing temperatures and time. They are able to encapsulate different fluorescent dyes, therapeutic drugs, radionuclides and even small proteins. While sharing many properties with lipid vesicles, the BAPCs are much more robust. They have been analyzed for stability, size, cellular uptake and localization, intra-cellular retention and, bio-distribution both in culture and in vivo.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Materiais Biomiméticos / Nanocápsulas Limite: Animals / Humans Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Materiais Biomiméticos / Nanocápsulas Limite: Animals / Humans Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos