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Vitamin A supplementation reduces the Th17-Treg - Related cytokines in obese and non-obese women.
Farhangi, Mahdieh Abbasalizad; Saboor-Yaraghi, Ali Akbar; Keshavarz, Seyyed Ali.
Afiliação
  • Farhangi MA; Department of Community Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Saboor-Yaraghi AA; Department of Cellular and Molecular Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
  • Keshavarz SA; Department of Clinical Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Arch Endocrinol Metab ; 60(1): 29-35, 2016 Feb.
Article em En | MEDLINE | ID: mdl-26909479
OBJECTIVE: The objective of the present study was to investigate the effect of vitamin A supplementation on serum Th17 (IL-6, IL-17, IFNγ) and Treg (TGF-ß, IL-10) related cytokines in obese and non-obese women. SUBJECTS AND METHODS: In a randomized double blind placebo controlled design, 56 obese women were randomly assigned to receive either an oral dose of 25,000 IU retinyl palmitate or placebo per day for 4 months. Twenty eight ages matched non-obese women were also received vitamin A. At the study entry, anthropometric variables were measured and serum Th17 and Treg related cytokine profile were determined at baseline and 4 months after intervention. RESULTS: Significantly higher baseline concentrations of IL-6 were observed in obese compared with non-obese women (P < 0.05). However, the initial concentrations of other cytokines were not significantly different between groups. The mean concentrations of IL-17 and TGF-ß were significantly decreased after vitamin A supplementation in non-obese and obese women respectively. Positive relationships between IL-17 and IL-10 (r = 0.42, P < 0.001), TGF-ß and IL-17 (r = 0.35, P < 0.001) and between IL-10 and IFN-γ (r = 0.41, P = 0.002) in total participants were also observed. CONCLUSIONS: The results of the present study showed for the first time that vitamin A supplementation reduces serum concentrations of IL-17 and TGF-ß in reproductive age women. Further studies are needed to explore the possible underlying mechanisms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina A / Vitaminas / Citocinas / Suplementos Nutricionais / Obesidade Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina A / Vitaminas / Citocinas / Suplementos Nutricionais / Obesidade Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil