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Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val) Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia among the Population of West Mexico.
Ramos-Lopez, Omar; Panduro, Arturo; Martinez-Lopez, Erika; Roman, Sonia.
Afiliação
  • Ramos-Lopez O; Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco 44280, Mexico. os_mar6@hotmail.com.
  • Panduro A; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico. os_mar6@hotmail.com.
  • Martinez-Lopez E; Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco 44280, Mexico. apanduro@prodigy.net.mx.
  • Roman S; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico. apanduro@prodigy.net.mx.
Nutrients ; 8(2): 101, 2016 Feb 19.
Article em En | MEDLINE | ID: mdl-26907331
Some high-carbohydrate diets may lead to obesity and multiple metabolic disorders, including hypertriglyceridemia (HTG). This lipid abnormality is considered an important risk factor for cardiovascular disease and type 2 diabetes. The sweet taste receptor TAS1R2 polymorphism (Ile191Val) has been reported to be associated with carbohydrate intake. The aim of this study was to analyze the association of the TAS1R2 gene polymorphism with carbohydrate intake and HTG among the population of West Mexico. In a cross-sectional study, 441 unrelated subjects were analyzed for TAS1R2 genotypes (Ile/Ile, Ile/Val and Val/Val) by an allelic discrimination assay. Biochemical tests and a three-day food record were assessed. The Val/Val genotype carriers had a higher intake of total carbohydrates, fiber and servings of cereals and vegetables than the other genotype carriers. The Val/Val genotype conferred a higher risk for HTG than the Ile/Val and Ile/Ile genotypes (OR = 3.26, 95%CI 1.35-7.86, p = 0.006 and OR = 2.61, 95%CI 1.12-6.07, p = 0.02, respectively). Furthermore, the Val/Val genotype was associated with approximately 30% higher triglycerides compared with Ile/Val and Ile/Ile genotypes (ß = 44.09, 95%CI 9.94-78.25, p = 0.01 and ß = 45.7, 95%CI 10.85-80.54, p = 0.01, respectively). In conclusion, the Val/Val genotype of TAS1R2 was associated with a higher carbohydrate intake and HTG.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paladar / Papilas Gustativas / Carboidratos da Dieta / Hipertrigliceridemia / Polimorfismo de Nucleotídeo Único / Receptores Acoplados a Proteínas G / Comportamento Alimentar Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Nutrients Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paladar / Papilas Gustativas / Carboidratos da Dieta / Hipertrigliceridemia / Polimorfismo de Nucleotídeo Único / Receptores Acoplados a Proteínas G / Comportamento Alimentar Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Nutrients Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Suíça