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Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences.
Bacurau, Aline V; Cunha, Telma F; Souza, Rodrigo W; Voltarelli, Vanessa A; Gabriel-Costa, Daniele; Brum, Patricia C.
Afiliação
  • Bacurau AV; School of Physical Education and Sport, University of São Paulo, 05508-030 São Paulo, SP, Brazil.
  • Cunha TF; School of Physical Education and Sport, University of São Paulo, 05508-030 São Paulo, SP, Brazil.
  • Souza RW; School of Physical Education and Sport, University of São Paulo, 05508-030 São Paulo, SP, Brazil.
  • Voltarelli VA; School of Physical Education and Sport, University of São Paulo, 05508-030 São Paulo, SP, Brazil.
  • Gabriel-Costa D; School of Physical Education and Sport, University of São Paulo, 05508-030 São Paulo, SP, Brazil.
  • Brum PC; School of Physical Education and Sport, University of São Paulo, 05508-030 São Paulo, SP, Brazil.
Oxid Med Cell Longev ; 2016: 4374671, 2016.
Article em En | MEDLINE | ID: mdl-26904163
Skeletal myopathy has been identified as a major comorbidity of heart failure (HF) affecting up to 20% of ambulatory patients leading to shortness of breath, early fatigue, and exercise intolerance. Neurohumoral blockade, through the inhibition of renin angiotensin aldosterone system (RAS) and ß-adrenergic receptor blockade (ß-blockers), is a mandatory pharmacological therapy of HF since it reduces symptoms, mortality, and sudden death. However, the effect of these drugs on skeletal myopathy needs to be clarified, since exercise intolerance remains in HF patients optimized with ß-blockers and inhibitors of RAS. Aerobic exercise training (AET) is efficient in counteracting skeletal myopathy and in improving functional capacity and quality of life. Indeed, AET has beneficial effects on failing heart itself despite being of less magnitude compared with neurohumoral blockade. In this way, AET should be implemented in the care standards, together with pharmacological therapies. Since both neurohumoral inhibition and AET have a direct and/or indirect impact on skeletal muscle, this review aims to provide an overview of the isolated effects of these therapeutic approaches in counteracting skeletal myopathy in HF. The similarities and dissimilarities of neurohumoral inhibition and AET therapies are also discussed to identify potential advantageous effects of these combined therapies for treating HF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Músculo Esquelético / Insuficiência Cardíaca / Doenças Musculares Tipo de estudo: Guideline Aspecto: Patient_preference Limite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Músculo Esquelético / Insuficiência Cardíaca / Doenças Musculares Tipo de estudo: Guideline Aspecto: Patient_preference Limite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos