Tagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing properties.
J Ethnopharmacol
; 181: 221-8, 2016 Apr 02.
Article
em En
| MEDLINE
| ID: mdl-26873624
ETHNOPHARMACOLOGICAL RELEVANCE: Morelos State is one of the most important regions of Mexico where several plant species are used in traditional medicine to influence central nervous system (CNS) activity; for example Tagetes lucida Cav. AIM OF THE STUDY: To investigate the ethnobotany, phytochemistry and pharmacology of the tranquilizing properties of T. lucida aerial parts. MATERIAL AND METHODS: Data on the medicinal uses of T. lucida were explored by interviewing healers and merchants of local markets in different regions of Morelos State by using a questionnaire. Anxiolytic and/or sedative-like responses of the T. lucida were investigated in experimental models in mice such as: open-field, exploration cylinder, hole-board, plus-maze, and the barbituric-induced hypnosis potentiation. The possible mechanism of action was explored in the presence of WAY100635 (0.32mg/kg, i.p.) and flumazenil (10mg/kg, i.p.) antagonists. A feasible active compound was isolated and identified by using conventional chromatography, including UHPLC and MS (DART) [M+H]+ techniques. RESULTS: Interviews of healers and merchants from ten local regions of Morelos State showed that they recommended T. lucida as infusion and as tincture for several culture-bound syndromes associated with the CNS. Anxiolytic and sedative-like activities of polar extracts were corroborated in the experimental models; these effects were inhibited in the presence of 5-HT1A and GABA/BDZ receptor antagonists. Dimethylfraxetin was identified as one possible active compound. CONCLUSIONS: The results support the anxiolytic and sedative-like properties of T. lucida in traditional medicine by involving serotonergic and GABAergic neurotransmission and coumarinic constituents.
Palavras-chave
Anxiety; Central nervous system; Coumarins; Diazepam (PubChem CID: 3016); Dimethylfraxetin (6,7,8-Trimethoxycoumarin) (PubChem CID: 3083928); Ethnobotany; Flumazenil (PubChem CID: 3373); Sedative; Sodium pentobarbital (PubChem CID: 23676152); Tagetes lucida; WAY100635 maleate salt (PubChem CID: 11957721)
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tranquilizantes
/
Extratos Vegetais
/
Etnobotânica
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Tagetes
/
Compostos Fitoquímicos
Limite:
Animals
País/Região como assunto:
Mexico
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2016
Tipo de documento:
Article
País de publicação:
Irlanda