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A structurally normal fetus at the 11- to 14-week ultrasound does not guarantee a newborn without congenital anomalies: a cohort study.
Mario Sarti, Angelo; Okido, Marcos Masaru; Araujo Júnior, Edward; Cavalli, Ricardo de Carvalho; Quintana, Silvana Maria; Duarte, Geraldo; Marcolin, Alessandra Cristina.
Afiliação
  • Mario Sarti A; a Department of Gynecology and Obstetrics , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil and.
  • Okido MM; a Department of Gynecology and Obstetrics , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil and.
  • Araujo Júnior E; b Department of Obstetrics , Paulista School of Medicine - Federal University of São Paulo , São Paulo , Brazil.
  • Cavalli Rde C; a Department of Gynecology and Obstetrics , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil and.
  • Quintana SM; a Department of Gynecology and Obstetrics , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil and.
  • Duarte G; a Department of Gynecology and Obstetrics , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil and.
  • Marcolin AC; a Department of Gynecology and Obstetrics , Ribeirão Preto Medical School, University of São Paulo , Ribeirão Preto , Brazil and.
J Matern Fetal Neonatal Med ; 29(24): 3960-6, 2016 Dec.
Article em En | MEDLINE | ID: mdl-26857452
OBJECTIVE: The objective of this study was to analyze the influence of maternal demographic characteristics and abnormal first-trimester sonographic markers on congenital anomalies (CAs) at birth when the fetus is structurally normal at the 11- to 14-week ultrasound. METHODS: This prospective cohort study comprised high-risk women undergoing routine antenatal care. Detailed assessments of fetal anatomy and first-trimester sonographic markers were performed at 11-14 weeks of pregnancy. Multilevel regression analysis was used to determine the effects of maternal characteristics and abnormal first-trimester sonographic markers on the incidence of CA at birth. RESULTS: Three hundred and ten patients were evaluated, and 41 patients (13.2%) had an anomalous newborn. The presence of a specific indication at the first-trimester ultrasound (OR: 2.72; CI 95% 1.09-6.74) or a nuchal translucency (NT) thickness greater than 2.5 mm increased the risk of CA at birth by three fold (OR: 3.10; CI 95% 1.07-9.59). High adjusted risks for trisomies 21, 18 and 13 increased the likelihood of having a structurally abnormal newborn by five, twelve and six fold, respectively. CONCLUSION: Increased NT and/or high adjusted risks for trisomies 21, 18, and 13 increase the risk of CA at birth, even in fetuses with a structurally normal 11- to 14-week ultrasound scan.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Primeiro Trimestre da Gravidez / Anormalidades Congênitas / Ultrassonografia Pré-Natal / Feto Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Newborn / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Matern Fetal Neonatal Med Assunto da revista: OBSTETRICIA / PERINATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Primeiro Trimestre da Gravidez / Anormalidades Congênitas / Ultrassonografia Pré-Natal / Feto Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Newborn / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Matern Fetal Neonatal Med Assunto da revista: OBSTETRICIA / PERINATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de publicação: Reino Unido