Your browser doesn't support javascript.
loading
Effects of different periods of paradoxical sleep deprivation and sleep recovery on lipid and glucose metabolism and appetite hormones in rats.
Brianza-Padilla, Malinalli; Bonilla-Jaime, Herlinda; Almanza-Pérez, Julio César; López-López, Ana Laura; Sánchez-Muñoz, Fausto; Vázquez-Palacios, Gonzalo.
Afiliação
  • Brianza-Padilla M; a Posgrado en Biología Experimental, Universidad Autónoma Metropolitana-Iztapalapa, CP 09340, Mexico.
  • Bonilla-Jaime H; b Departamento de Biología de la Reproducción, Área de Biología Conductual y Reproductiva, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco No. 186, Col. Vicentina, CP 09340, Mexico.
  • Almanza-Pérez JC; c Departamento de Ciencias de la Salud, Área de Investigación Médica, Universidad Autónoma Metropolitana-Iztapalapa, CP 09340, Mexico.
  • López-López AL; a Posgrado en Biología Experimental, Universidad Autónoma Metropolitana-Iztapalapa, CP 09340, Mexico.
  • Sánchez-Muñoz F; d Departamento de Inmunología, Instituto Nacional de Cardiologia (Ignacio Chávez), Juan Badiano No. 1, Col. Sección XVI, Del. Tlalpan, CP 14080, Mexico.
  • Vázquez-Palacios G; e Colegio de Ciencias y Humanidades, Universidad Autónoma de la Ciudad de México-San Lorenzo Tezonco, Av. Prolongación San Isidro No. 151, Col. San Lorenzo Tezonco, Del. Iztapalapa, CP 09790, Mexico.
Appl Physiol Nutr Metab ; 41(3): 235-43, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26842666
Sleep has a fundamental role in the regulation of energy balance, and it is an essential and natural process whose precise impacts on health and disease have not yet been fully elucidated. The aim of this study was to assess the consequences of different periods of paradoxical sleep deprivation (PSD) and recovery from PSD on lipid profile, oral glucose tolerance test (OGTT) results, and changes in insulin, corticosterone, ghrelin, and leptin concentrations. Three-month-old male Wistar rats weighing 250-350 g were submitted to 24, 96, or 192 h of PSD or 192 h of PSD with 480 h of recovery. The PSD was induced by the multiple platforms method. Subsequently, the animals were submitted to an OGTT. One day later, the animals were killed and the levels of triglycerides, total cholesterol, lipoproteins (low-density lipoprotein, very-low-density lipoprotein, and high-density lipoprotein), insulin, ghrelin, leptin, and corticosterone in plasma were quantified. There was a progressive decrease in body weight with increasing duration of PSD. The PSD induced basal hypoglycemia over all time periods evaluated. Evaluation of areas under the curve revealed progressive hypoglycemia only after 96 and 192 h of PSD. There was an increase in corticosterone levels after 192 h of PSD. We conclude that PSD induces alterations in metabolism that are reversed after a recovery period of 20 days.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação do Apetite / Sono / Privação do Sono / Glicemia / Hormônios / Lipídeos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Appl Physiol Nutr Metab Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA ESPORTIVA / METABOLISMO Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Canadá
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação do Apetite / Sono / Privação do Sono / Glicemia / Hormônios / Lipídeos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Appl Physiol Nutr Metab Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA ESPORTIVA / METABOLISMO Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Canadá