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The Correlation Between Obesity-Related Diseases and Non-alcoholic Fatty Liver Disease in Women in the Pre-operative Evaluation for Bariatric Surgery Assessed by Transient Hepatic Elastography.
de Barros, Fernando; Setúbal, Sérgio; Martinho, José Manoel; Leite, Nathalie Carvalho; Guaraná, Thais; Monteiro, Ana Beatriz Soares; Villela-Nogueira, Cristiane A.
Afiliação
  • de Barros F; FIOCRUZ / Andarai Federal Hospital, Rio de Janeiro, RJ, Brazil. barroscirurgia@gmail.com.
  • Setúbal S; Postgraduate Program, Fluminense Federal University, Niterói, RJ, Brazil. barroscirurgia@gmail.com.
  • Martinho JM; , 118 João Lira St, Apt 102, Leblon, Rio de Janeiro, 22430-210, RJ, Brazil. barroscirurgia@gmail.com.
  • Leite NC; Postgraduate Program in Medical Sciences, Fluminense Federal University, Niterói, RJ, Brazil.
  • Guaraná T; Department of General Surgery, Fluminense Federal University, Niterói, RJ, Brazil.
  • Monteiro ABS; Internal Medicine Division, Rio de Janeiro Federal University, Rio de Janeiro, RJ, Brazil.
  • Villela-Nogueira CA; Department of Gastroenterology, Fluminense Federal University, Niteroi, RJ, Brazil.
Obes Surg ; 26(9): 2089-2097, 2016 09.
Article em En | MEDLINE | ID: mdl-26803754
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common, severe disease in obese patients. However, NAFLD is usually underestimated by ultrasonography. Liver biopsy is not routinely done in bariatric surgery or during the follow-up. This study therefore examined the correlation between metabolic syndrome and NAFLD in morbidly obese patients based on an assessment using transient hepatic elastography (THE). MATERIAL AND METHODS: This study involved 50 female patients in the pre-operative phase for bariatric surgery. Before surgery, we collected clinical, laboratory, and anthropometric variables. THE measurements were obtained using a FibroScan® device (Echosens, Paris, France), and steatosis was quantified using Controlled Attenuation Parameter software (CAP). Statistical analyses were done using linear correlation and the Kruskal-Wallis test. RESULTS: The mean of THE and CAP values were 7.56 ± 4.78 kPa and 279.94 ± 45.69 dB/m, respectively, and there was a significant linear correlation between the two measurements (r = 0.651; p < 0.001). The numbers of metabolic syndrome parameters did not influence the THE (p = 0.436) or CAP (p = 0.422) values. HbA1c and HOMA-IR showed a strong linear correlation with CAP (r = 0.643, p = 0.013 and r = 0.668, p = 0.009, respectively) and a tendency to some linear correlation with THE (r = 0.500, p = 0.05 and r = 0.500, p = 0.002, respectively). CONCLUSION: Morbidly obese women submitted to FibroScan® presented a high prevalence of severe steatosis and advanced fibrosis in our sample. Insulin resistance parameters were correlated with steatosis, but less with fibrosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Obesidade Mórbida / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Diagnostic_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: Europa Idioma: En Revista: Obes Surg Assunto da revista: METABOLISMO Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Obesidade Mórbida / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Diagnostic_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: Europa Idioma: En Revista: Obes Surg Assunto da revista: METABOLISMO Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos