Biomechanical Properties and Microstructural Analysis of the Human Nonaneurysmal Aorta as a Function of Age, Gender and Location: An Autopsy Study.
J Vasc Res
; 52(4): 257-64, 2015.
Article
em En
| MEDLINE
| ID: mdl-26799837
INTRODUCTION: The biomechanical failure properties and histological composition of the human nonaneurysmal aorta were studied. METHODS: Twenty-six human aortas were harvested from fresh cadavers at autopsy. A total of 153 circumferentially oriented strips were obtained from the aortas for biomechanical and histological studies. RESULTS: The failure load (6.18 ± 2.03 vs. 4.85 ± 2.04 N; p = 0.001), failure tension (19.88 ± 9.05 vs. 14.53 ± 7 N/cm; p = 0.001), failure strain (0.66 ± 0.31 vs. 0.49 ± 0.25; p = 0.003) and amount of elastic fibers (19.39 ± 15.57 vs. 14.06 ± 9.5%; p = 0.011) were all significantly higher for the thoracic than the abdominal aorta. There was a significant negative correlation between age and failure load (R = -0.35; p < 0.0001), failure stress (R = -0.63; p < 0.0001), failure tension (R = -0.52; p < 0.0001) and failure strain (R = -0.8; p < 0.0001). Male aortas had a higher failure load and failure tension than female aortas. CONCLUSION: The thoracic aorta has a higher strength and elasticity than the abdominal aorta. The elderly have weaker and stiffer aortas than the young. Male aortas are stronger than female aortas.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aorta Abdominal
/
Aorta Torácica
/
Envelhecimento
/
Rigidez Vascular
Aspecto:
Determinantes_sociais_saude
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Vasc Res
Assunto da revista:
ANGIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Suíça