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Effect of odanacatib on root resorption and alveolar bone metabolism during orthodontic tooth movement.
Wei, X X; Chu, J P; Zou, Y Z; Ru, N; Cui, S X; Bai, Y X.
Afiliação
  • Wei XX; Department of Orthodontics, Capital Medical University School of Stomatology, Beijing, China.
  • Chu JP; Department of Orthodontics, Zhengzhou University School of Stomatology, Zhengzhou, China.
  • Zou YZ; Department of Endodontics, Zhengzhou University School of Stomatology, Zhengzhou, China.
  • Ru N; Department of Orthodontics, Zhengzhou University School of Stomatology, Zhengzhou, China.
  • Cui SX; Department of Orthodontics, Capital Medical University School of Stomatology, Beijing, China.
  • Bai YX; Department of Orthodontics, Zhengzhou University School of Stomatology, Zhengzhou, China.
Genet Mol Res ; 14(4): 17972-81, 2015 Dec 22.
Article em En | MEDLINE | ID: mdl-26782444
The aim of this study was to investigate the effect of local administration of odanacatib (ODN) on orthodontic root resorption and the status of alveolar bone metabolism in rat molars. All specimens were scanned using microcomputed tomography and then the raw images were reconstructed. The total volume of the root resorption craters of the 60 g-NS (normal saline) group was higher than in the 60 g-ODN group and the control group. In the 60 g-NS group, the bone volume fraction values of alveolar bone were significantly decreased compared with the other 2 groups. There were no significant differences in the bone volume fraction values of the tibiae among the 3 groups. The results of tartrate-resistant acid phosphatase-positive (TRAP+) numbers showed that there was no difference between the 60 g-NS group and the 60 g-ODN group. The expression of cathepsin K was decreased significantly in the 60 g-ODN group. These results indicate that ODN reduces orthodontics-induced external root resorption and increases alveolar bone metabolism. This may be because ODN inhibits the activity of odontoclasts, but maintains the quantity of odontoclasts and enhances bone formation. ODN promotes local alveolar bone metabolism, but does not affect systemic bone metabolism.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reabsorção da Raiz / Compostos de Bifenilo / Osso e Ossos / Perda do Osso Alveolar Limite: Animals / Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reabsorção da Raiz / Compostos de Bifenilo / Osso e Ossos / Perda do Osso Alveolar Limite: Animals / Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil