Mitochondrial ND3 G10398A mutation: a biomarker for breast cancer.

Yu, Y; Lv, F; Lin, H; Qian, G; Jiang, Y S; Pang, L X; Wang, Y P; Wang, X F; Kang, Y M; Li, C B; Liu, Q; Xu, J Z; You, W

Yu, Y; Lv, F; Lin, H; Qian, G; Jiang, Y S; Pang, L X; Wang, Y P; Wang, X F; Kang, Y M; Li, C B; Liu, Q; Xu, J Z; You, W.

Afiliação

Yu Y; Department of Breast Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Lv F; Department of Breast Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
Lin H; College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Qian G; Department of Endocrinology, Ningbo Fourth Hospital, Xiangshan, China.
Jiang YS; Department of Endocrinology, Ningbo Fourth Hospital, Xiangshan, China.
Pang LX; College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Wang YP; College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Wang XF; College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Kang YM; School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, China.
Li CB; School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, China.
Liu Q; Department of Clinical Laboratory Center, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, China.
Xu JZ; Department of Clinical Pharmacy, The Affiliated Wenling Hospital of Wenzhou Medial University, Wenling, China.
You W; Department of Breast Surgery, Henan Provincial People's Hospital, Zhengzhou, China.

Genet Mol Res ; 14(4): 17426-31, 2015 Dec 21.

Article em En | MEDLINE | ID: mdl-26782384

RESUMO

Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and molecular datasets from case-control studies to determine the association between the G10398A mutation and breast cancer. We further used the Phylotree to determine the haplogroups of this mutation. The frequencies of this mutation in 500 unrelated healthy controls were also screened. We found that this mutation is very common in the human population, and may be a polymorph.

Assuntos

Biomarcadores Tumorais/genética; Neoplasias da Mama/genética; Carcinogênese; Complexo I de Transporte de Elétrons/genética; Substituição de Aminoácidos/genética; Neoplasias da Mama/patologia; Estudos de Casos e Controles; DNA Mitocondrial/genética; Feminino; Humanos; Mutação

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Biomarcadores Tumorais / Complexo I de Transporte de Elétrons / Carcinogênese Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

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