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Serotonin 2a Receptor and Serotonin 1a Receptor Interact Within the Medial Prefrontal Cortex During Recognition Memory in Mice.
Morici, Juan F; Ciccia, Lucia; Malleret, Gaël; Gingrich, Jay A; Bekinschtein, Pedro; Weisstaub, Noelia V.
Afiliação
  • Morici JF; Systems Neuroscience Group, Laboratory of Experimental Cognition and Behavior, Institute of Physiology and Biophysics, IFIBIO "Houssay," CONICET and University of Buenos Aires Medical School Buenos Aires, Argentina.
  • Ciccia L; Systems Neuroscience Group, Laboratory of Experimental Cognition and Behavior, Institute of Physiology and Biophysics, IFIBIO "Houssay," CONICET and University of Buenos Aires Medical School Buenos Aires, Argentina.
  • Malleret G; Lyon Neuroscience Research Center, Centre National de la Recherche Scientifique UMR 5292 - Institut National de la Santé et de la Recherche Médicale U1028 - Université Claude Bernard Lyon1 Lyon, France.
  • Gingrich JA; Sackler Institute for Developmental Psychobiology, Columbia University, New YorkNY, USA; New York State Psychiatric InstituteNew York, NY, USA.
  • Bekinschtein P; Laboratory of Memory Research and Molecular Cognition, Institute for Cell Biology and Neuroscience, CONICET and University of Buenos Aires Medical School Buenos Aires, Argentina.
  • Weisstaub NV; Systems Neuroscience Group, Laboratory of Experimental Cognition and Behavior, Institute of Physiology and Biophysics, IFIBIO "Houssay," CONICET and University of Buenos Aires Medical School Buenos Aires, Argentina.
Front Pharmacol ; 6: 298, 2015.
Article em En | MEDLINE | ID: mdl-26779016
Episodic memory, can be defined as the memory for unique events. The serotonergic system one of the main neuromodulatory systems in the brain appears to play a role in it. The serotonin 2a receptor (5-HT2aR) one of the principal post-synaptic receptors for 5-HT in the brain, is involved in neuropsychiatric and neurological disorders associated with memory deficits. Recognition memory can be defined as the ability to recognize if a particular event or item was previously encountered and is thus considered, under certain conditions, a form of episodic memory. As human data suggest that a constitutively decrease of 5-HT2A signaling might affect episodic memory performance we decided to compare the performance of mice with disrupted 5-HT2aR signaling (htr2a (-/-)) with wild type (htr2a (+/+)) littermates in different recognition memory and working memory tasks that differed in the level of proactive interference. We found that ablation of 5-HT2aR signaling throughout development produces a deficit in tasks that cannot be solved by single item strategy suggesting that 5-HT2aR signaling is involved in interference resolution. We also found that in the absence of 5-HT2aR signaling serotonin has a deleterious effect on recognition memory retrieval through the activation of 5-HT1aR in the medial prefrontal cortex.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça