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Cardiovascular disease risks in adult Native and Mexican Americans with a history of alcohol use disorders: association with cardiovascular autonomic control.
Criado, José R; Gilder, David A; Kalafut, Mary A; Ehlers, Cindy L.
Afiliação
  • Criado JR; Scripps Autonomic Neuro Lab, Division of Neurology, Scripps Clinic, 10666 North Torrey Pines Rd., MS-313, La Jolla, CA, 92037, USA. criado.jose@scrippshealth.org.
  • Gilder DA; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA. criado.jose@scrippshealth.org.
  • Kalafut MA; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Ehlers CL; Scripps Autonomic Neuro Lab, Division of Neurology, Scripps Clinic, 10666 North Torrey Pines Rd., MS-313, La Jolla, CA, 92037, USA.
Clin Auton Res ; 26(2): 87-95, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26758567
Hypertension and obesity are serious health problems that have been associated with an increased risk of cardiovascular disease (CVD). We recently showed a relationship between hypertension, obesity and cardiovagal control in a sample of Native and Mexican Americans at high risk of alcohol use disorders (AUD). While studies have shown that Native and Mexican Americans exhibit high rates of AUD, the consequences of AUD on CVD risk factors and their relationship with cardiovascular autonomic control is not well understood in these ethnic groups. This study investigated whether an association could be demonstrated between cardiovascular autonomic control and several CVD risk factors in Native and Mexican American men and women (n = 228) who are literate in English and are residing legally in San Diego County. Participants with lifetime history of AUD showed higher rates of systolic and diastolic hypertension and obesity than participants without lifetime AUD. Lifetime AUD was significantly associated with reduced HR response to deep breathing (HRDB) measure of cardiovagal control, higher current drinking quantity, and obesity. Reduced HRDB was also associated with increased systolic pre-hypertension or hypertension (pre-/hypertension) and with higher diastolic blood pressure in a linear regression model that included several diagnostic and demographic variables. HRDB and time- and frequency-domain measures of cardiovagal control were significantly reduced in participants with diastolic pre-/hypertension. These data suggest that lower cardiovagal control may play a role in the prevalence of systolic and diastolic pre-/hypertension in a community sample with a history of alcohol and substance use disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Autônomo / Doenças Cardiovasculares / Fenômenos Fisiológicos Cardiovasculares / Alcoolismo Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Clin Auton Res Assunto da revista: NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Autônomo / Doenças Cardiovasculares / Fenômenos Fisiológicos Cardiovasculares / Alcoolismo Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Clin Auton Res Assunto da revista: NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Alemanha