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Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro.
Brilhante, Raimunda Sâmia Nogueira; Caetano, Érica Pacheco; Riello, Giovanna Barbosa; Guedes, Glaucia Morgana de Melo; Castelo-Branco, Débora de Souza Collares Maia; Fechine, Maria Auxiliadora Bezerra; Oliveira, Jonathas Sales de; Camargo, Zoilo Pires de; Mesquita, Jacó Ricarte Lima de; Monteiro, André Jalles; Cordeiro, Rossana de Aguiar; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa.
Afiliação
  • Brilhante RS; Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil; Postgraduate Program in Medical Sciences, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil. Electronic address: brilhante@ufc.br.
  • Caetano ÉP; Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
  • Riello GB; Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
  • Guedes GM; Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
  • Castelo-Branco Dde S; Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil; Postgraduate Program in Medical Sciences, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
  • Fechine MA; Postgraduate Program in Medical Sciences, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
  • Oliveira JS; Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
  • Camargo ZP; Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
  • Mesquita JR; Hospital São José, Fortaleza, CE, Brazil.
  • Monteiro AJ; Department of Statistics and Applied Mathematics, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
  • Cordeiro Rde A; Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil; Postgraduate Program in Medical Sciences, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
  • Rocha MF; Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil; Postgraduate Program in Veterinary Sciences, Universidade Estadual do Ceará (UECE), Fortaleza, CE, Brazil.
  • Sidrim JJ; Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil; Postgraduate Program in Medical Sciences, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
Braz J Infect Dis ; 20(2): 155-9, 2016.
Article em En | MEDLINE | ID: mdl-26748233
Recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. The susceptibility assay was performed according to Clinical and Laboratory Standards Institute guidelines. All strains were inhibited by the protease inhibitor antiretroviral drugs. Saquinavir showed minimum inhibitory concentrations ranging from 0.125 to 1µgmL(-1) for both phases, and ritonavir presented minimum inhibitory concentrations ranging from 0.0312 to 4µgmL(-1)and from 0.0625 to 1µgmL(-1) for filamentous and yeast phase, respectively. Concerning the antifungal itraconazole, the minimum inhibitory concentration values ranged from 0.0019 to 0.125µgmL(-1) and from 0.0039 to 0.0312µgmL(-1) for the filamentous and yeast phase, respectively. The combination of saquinavir or ritonavir with itraconazole was synergistic against H. capsulatum, with a significant reduction in the minimum inhibitory concentrations of both drugs against the strains (p<0.05). These data show an important in vitro synergy between protease inhibitors and itraconazole against the fungus H. capsulatum.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Protease de HIV / Itraconazol / Ritonavir / Saquinavir / Histoplasma / Antifúngicos Tipo de estudo: Guideline Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Protease de HIV / Itraconazol / Ritonavir / Saquinavir / Histoplasma / Antifúngicos Tipo de estudo: Guideline Idioma: En Revista: Braz J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil