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Male Gender and Body Mass Index Are Associated With Hypertension and Reduced Kidney Function 5 or More Years After Living Kidney Donation.
Bello, R C; Bello, V A; Rosa, T T; Junqueira, L F; Freitas, E; Veiga, J P R.
Afiliação
  • Bello RC; Department of Nephrology and Transplant of the Federal District Hospital, Brasilia, Brazil. Electronic address: robertacasanovas@terra.com.
  • Bello VA; Department of Nephrology and Transplant of the Federal District Hospital, Brasilia, Brazil.
  • Rosa TT; Division of Nephrology, Catholic University, Faculty of Medicine, Brasilia, Brazil.
  • Junqueira LF; Division of Cardiology, University of Brasilia Hospital, Faculty of Medicine, Brasilia, Brazil.
  • Freitas E; Department of Statistics, University of Brasilia Hospital, Faculty of Medicine, Brasilia, Brazil.
  • Veiga JP; Division of Nephrology, University of Brasilia Hospital, Faculty of Medicine, Brasilia, Brazil.
Transplant Proc ; 47(10): 2816-21, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26707294
BACKGROUND: The objective of this study was to evaluate renal function and to explore the relationship between some risk factors in kidney donors 12.37 ± 7.60 years after donation. PATIENTS AND METHODS: In a cross-sectional study conducted in a transplant unit, 77 nephrectomized subjects were assessed ≥5 years after donation to evaluate their renal function and the presence or absence of hypertension, dyslipidemia, and microalbuminuria. RESULTS: Twenty donors had an estimated glomerular filtration rate of <60 mL/min/1.73 m(2). Nine donors showed urinary albumin excretion of >20 µg/min (11.68%). Subjects with an EGFR of <60 mL/min were predominantly male and hypertensive and showed higher body mass index (BMI), higher uric acid, higher total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C), and logarithm of triglycerides/HDL-C (log TG/HDL-C) ratios than donors with an EGFR of >60 mL/min. Hypertensive donors were older and had higher BMI, higher UA serum values, higher TC/HDL-C and log TG/HDL-C ratios and microalbuminuria than nonhypertensive donors (P < .005). A multivariate analysis was conducted and, after final adjustment, a filtration rate of <60 mL/min was 3.05 times higher in men than women, increased 10% for each 1-unit increase in BMI and was positively associated with log (TG/HDL-C). The frequency of hypertension increased by 10% for each 1-unit increase in BMI and was positively associated with microalbuminuria. CONCLUSION: In this sample of kidney donors from a single transplant unit, ≥5 years after donation, male sex and high BMI were positively associated with the presence of kidney failure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Rim / Doadores Vivos / Insuficiência Renal / Hipertensão Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Transplant Proc Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Rim / Doadores Vivos / Insuficiência Renal / Hipertensão Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Transplant Proc Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos