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Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events.
Cho, Sung Woo; Kim, Byung Gyu; Kim, Byung Ok; Byun, Young Sup; Goh, Choong Won; Rhee, Kun Joo; Kwon, Hyuck Moon; Lee, Byoung Kwon.
Afiliação
  • Cho SW; College of Medicine, Inje University, Seoul, Korea.
  • Kim BG; College of Medicine, Inje University, Seoul, Korea.
  • Kim BO; College of Medicine, Inje University, Seoul, Korea.
  • Byun YS; College of Medicine, Inje University, Seoul, Korea.
  • Goh CW; College of Medicine, Inje University, Seoul, Korea.
  • Rhee KJ; College of Medicine, Inje University, Seoul, Korea.
  • Kwon HM; College of Medicine, Yonsei University, Seoul, Korea.
  • Lee BK; College of Medicine, Yonsei University, Seoul, Korea.
Arq Bras Cardiol ; 106(1): 56-61, 2016 Jan.
Article em En, Pt | MEDLINE | ID: mdl-26690693
BACKGROUND: Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. OBJECTIVE: To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. METHODS: 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. RESULTS: Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. CONCLUSION: Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Fibrinogênio / Hemoglobinas Glicadas / Doenças Cardiovasculares / Doença das Coronárias / HDL-Colesterol Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Fibrinogênio / Hemoglobinas Glicadas / Doenças Cardiovasculares / Doença das Coronárias / HDL-Colesterol Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil