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High-fat diet during pregnancy and lactation impairs the cholinergic anti-inflammatory pathway in the liver and white adipose tissue of mouse offspring.
Payolla, Tanyara Baliani; Lemes, Simone Ferreira; de Fante, Thaís; Reginato, Andressa; Mendes da Silva, Cristiano; de Oliveira Micheletti, Thayana; Rodrigues, Hosana Gomes; Torsoni, Adriana Souza; Milanski, Marciane; Torsoni, Marcio Alberto.
Afiliação
  • Payolla TB; School of Applied Sciences, University of Campinas, Brazil.
  • Lemes SF; Biology Institute, University of Campinas, Brazil.
  • de Fante T; School of Applied Sciences, University of Campinas, Brazil.
  • Reginato A; School of Applied Sciences, University of Campinas, Brazil.
  • Mendes da Silva C; Department of Biosciences, Federal University of São Paulo, Brazil; Obesity and Comorbidities Research Center, State University of Campinas, Brazil.
  • de Oliveira Micheletti T; School of Applied Sciences, University of Campinas, Brazil.
  • Rodrigues HG; School of Applied Sciences, University of Campinas, Brazil.
  • Torsoni AS; School of Applied Sciences, University of Campinas, Brazil; Department of Biosciences, Federal University of São Paulo, Brazil; Obesity and Comorbidities Research Center, State University of Campinas, Brazil.
  • Milanski M; School of Applied Sciences, University of Campinas, Brazil; Department of Biosciences, Federal University of São Paulo, Brazil; Obesity and Comorbidities Research Center, State University of Campinas, Brazil.
  • Torsoni MA; School of Applied Sciences, University of Campinas, Brazil; Department of Biosciences, Federal University of São Paulo, Brazil; Obesity and Comorbidities Research Center, State University of Campinas, Brazil. Electronic address: marcio.torsoni@fca.unicamp.br.
Mol Cell Endocrinol ; 422: 192-202, 2016 Feb 15.
Article em En | MEDLINE | ID: mdl-26687064
Cholinergic anti-inflammatory pathway (CAP) prevents inflammatory cytokines production. The main was to evaluate the effect of maternal obesity on cholinergic pathway in the offspring. Female mice were subjected to either standard chow (SC) or high-fat diet (HFD) during pregnancy and the lactation period. After weaning, only male offspring from HFD dams (HFD-O) and from SC dams (SC-O) were fed the SC diet. Key proteins of the CAP were downregulated and serum TNF-α was elevated in the HFD-O mice. STAT3 and NF-κB activation in HFD-O mice ICV injected with nicotine (agonist) were lower than SC-O mice. Basal cholinesterase activity was upregulated in HFD-O mice in both investigated tissues. Lipopolysaccharide increased TNF-α and IL-1ß expression in the liver and WAT of SC-O mice, but this effect was greater in HFD-O mice. In conclusion these changes exacerbated cytokine production in response to LPS and contributed to the reduced sensitivity of the CAP.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lactação / Gravidez / Tecido Adiposo Branco / Dieta Hiperlipídica / Receptor Nicotínico de Acetilcolina alfa7 / Fígado / Obesidade Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lactação / Gravidez / Tecido Adiposo Branco / Dieta Hiperlipídica / Receptor Nicotínico de Acetilcolina alfa7 / Fígado / Obesidade Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda